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DOI: 10.1055/s-0037-1611551
A Simple Method for the Preparation of Stainless and Highly Pure Trichloroacetimidates
The Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan supported the program for the Strategic Research Foundation at Private Universities (Grant No. S1311046), and the Japan Society for the Promotion of Science (JSPS) (KAKENHI) (Grant No. JP16H01163 in Middle Molecular Strategy, and Grant No. JP16KT0061) partly supported this work.Publikationsverlauf
Received: 10. April 2019
Accepted after revision: 29. April 2019
Publikationsdatum:
15. Mai 2019 (online)


Abstract
We describe a method for obtaining various allylic, benzylic, and glucosyl 2,2,2-trichloroacetimidates (TCAIs) as stainless liquids or solids at the crude stage. The general synthetic method for the preparation of TCAIs often leads to stained products, and further purification of crude TCAIs causes decomposition due to their instability. In the described method, we use a solvent that barely dissolves the reactant, providing stainless and sufficiently pure TCAIs without requiring a purification step. Furthermore, the reaction mixture is turbid at the beginning and clear at the end, allowing us to monitor the progress of the reaction visually.
Key words
preparation - 2,2,2-trichloroacetimidates - stainless - solvent optimization - visual detectionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611551.
- Supporting Information