Electrochemical C(sp³)–H Fluorination

Published as part of the Cluster Electrochemical Synthesis and Catalysis

Abstract

A simple and robust method for electrochemical alkyl C–H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C–H bonds are converted into their C–F congeners. The scalability of the reaction is also demonstrated with a 100 gram preparation of fluorovaline.

Key words

organic synthesis - electrochemistry - fluorination - C–H functionalization - radicals

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