Expanding the ¹⁸F-Radiochemical Space: Synthesis and Applications of 1,1-¹⁸F-Difluorinated Alkenes

Abstract

The synthesis of ¹⁸F-perfluorinated motifs from [¹⁸F]fluoride is a non-trivial undertaking as highlighted by the few methods and range of motifs that are known. In this Synpacts article we highlight our recent work on the synthesis and derivatization of 1,1-¹⁸F-difluoroalkenes to expand the accessible radiochemical space with fluorine-18.

1 Introduction

2 Overview of the Main Strategies to Access ¹⁸F-Perfluorinated Motifs with [¹⁸F]Fluoride

3 1,1-¹⁸F-Difluoroalkenes

4 Conclusion

Key words

fluorine-18 - radiochemistry - fluorination - gem-difluoroalkenes - perfluorination

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