Recent Advances in Electrochemistry for the Synthesis of N-Heterocycles

Abstract

The construction of N-heterocyclic rings represents a very important and fast-developing area of organic synthesis. In this context, electrochemistry has emerged as a mild solution for generating in situ the required electrophilic substrates, bases and nucleophiles derived from low-level and extremely stable reagents, the further application of which makes some heterocycles more accessible. In this review, we have covered the recent advances in the electrochemical synthesis of five- and six-membered N-heterocyclic compounds published from 2017 to October 2018.

1 Introduction

2 Electrochemical Synthesis of Five-Membered N-Containing Heterocycles

2.1 Pyrrolidines

2.2 Imidazoles

2.3 Pyrazoles

2.4 Triazoles

2.5 Oxazoles

2.6 Indoles

2.7 Thiazoless

3 Electrochemical Synthesis of Six-Membered N-Containing Heterocycles

3.1 Piperidines and Pyridines

3.2 Quinazolinones

3.3 Benzoxazines

4 Conclusions

Key words

azine - azole - direct and indirect electrolysis - N-containing heterocycles

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