Synthesis 2019; 51(12): 2455-2473
DOI: 10.1055/s-0037-1611797
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Advances in Electrochemistry for the Synthesis of N-Heterocycles

Najoua Sbei
,
Anna V. Listratova
,
Alexander A. Titov
,
Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation   Email: voskresenskiy-lg@rudn.ru
› Author Affiliations
The publication was prepared with the support of the ‘RUDN University Program 5-100’ and the Russian Foundation for Basic Research (grant 17-03-00605).
Further Information

Publication History

Received: 18 February 2019

Accepted after revision: 22 March 2019

Publication Date:
07 May 2019 (online)


Abstract

The construction of N-heterocyclic rings represents a very important and fast-developing area of organic synthesis. In this context, electrochemistry has emerged as a mild solution for generating in situ the required electrophilic substrates, bases and nucleophiles derived from low-level and extremely stable reagents, the further application of which makes some heterocycles more accessible. In this review, we have covered the recent advances in the electrochemical synthesis of five- and six-membered N-heterocyclic compounds published from 2017 to October 2018.

1 Introduction

2 Electrochemical Synthesis of Five-Membered N-Containing Heterocycles

2.1 Pyrrolidines

2.2 Imidazoles

2.3 Pyrazoles

2.4 Triazoles

2.5 Oxazoles

2.6 Indoles

2.7 Thiazoless

3 Electrochemical Synthesis of Six-Membered N-Containing Heterocycles

3.1 Piperidines and Pyridines

3.2 Quinazolinones

3.3 Benzoxazines

4 Conclusions