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Synthesis 2019; 51(15): 2891-2896
DOI: 10.1055/s-0037-1611836
DOI: 10.1055/s-0037-1611836
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Synthesis of N-Pyridyl Hydroxylamines via Copper-Catalyzed Cross-Coupling
U.S. Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO, CB10243) is acknowledged for the financial support.Further Information
Publication History
Received: 21 March 2019
Accepted after revision: 26 April 2019
Publication Date:
15 May 2019 (online)
Abstract
N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28–90% yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611836.
- Supporting Information
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Examples of nitroso ene and nitroso aldol reactions:
Turbo Grignard reactions: