Platelets Abolish the Profibrinolytic Effect of Activated Protein C

Mario Colucci; Bianca Maria Binetti; Nicola Semeraro

doi:10.1055/s-0037-1614142

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 84(05): 922-923
DOI: 10.1055/s-0037-1614142

Letters to the Editor

Schattauer GmbH

Platelets Abolish the Profibrinolytic Effect of Activated Protein C

Mario Colucci

¹From the Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy

,

Bianca Maria Binetti

¹From the Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy

,

Nicola Semeraro

¹From the Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy

› Author Affiliations

Abstract

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References

References
1 Esmon CT. Regulation of blood coagulation. Biochim Biophys Acta 2000; 1477: 349-60.
2 De Fouw N, Haverkate F, Bertina RM. Protein C and fibrinolysis: a link between coagulation and fibrinolysis. Adv Exp Med Biol 1990; 281: 235-43.
3 Bajzar L, Nesheim ME, Tracy PB. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 1996; 88: 2093-100.
4 Sakharov DV, Plow EF, Rijken DC. On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B. J Biol Chem 1997; 272: 14477-82.
5 Bertina RM. Molecular risk factors for thrombosis. Thromb Haemost 1999; 82: 601-9.
6 Taube J, Mc NWilliam, Luddington R, Byrne CD, Baglin T. Activated protein C resistance: effect of platelets, platelet-derived microparticles, and atherogenic lipoproteins. Blood 1999; 93: 3792-7.
7 Camire RM, Kalafatis M, Simioni P, Girolami A, Tracy PB. Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C. Blood 1998; 91: 2818-29.
8 Minnema MC, Friederich PW, Levi M, von dem Borne PA, Mosnier LO, Meijers JCM, Biemond BJ, Hack CE, Bouma BN, ten Cate H. Enhancement of rabbit jugular vein thrombosis by neutralization of factor XI. J Clin Invest 1998; 101: 10-4.
9 Gresele P, Momi S, Berrettini M, Nenci GG, Schwarz HP, Semeraro N, Colucci M. Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein C reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation. J Clin Invest 1998; 101: 667-76.