Download PDF
Thromb Haemost 1998; 79(01): 32-37
DOI: 10.1055/s-0037-1614214
Review Article
Schattauer GmbH

D-dimer Strategy in Thrombosis Exclusion

A Gold Standard Study in 100 Patients Suspected of Deep Venous Thrombosis or Pulmonary Embolism: 8 DD Methods Compared
G. Freyburger
1   From the Laboratoire d’Hématologie, Bordeaux, France
,
H. Trillaud
2   From the Service de Radiologie, Hôpital Pellegrin, Université BxII, Bordeaux, France
,
S. Labrouche
1   From the Laboratoire d’Hématologie, Bordeaux, France
,
P. Gauthier
2   From the Service de Radiologie, Hôpital Pellegrin, Université BxII, Bordeaux, France
,
S. Javorschi
1   From the Laboratoire d’Hématologie, Bordeaux, France
,
P. Bernard
1   From the Laboratoire d’Hématologie, Bordeaux, France
,
N. Grenier
2   From the Service de Radiologie, Hôpital Pellegrin, Université BxII, Bordeaux, France
› Author Affiliations
Further Information

Publication History

Received 15 May 1997

Accepted after resubmission 29 August 1997

Publication Date:
08 December 2017 (online)

Also available at
    Permissions and Reprints

Summary

DD are now recognized as a valuable tool to screen patients suspected of deep venous thrombosis or pulmonary embolism before carrying out a gold standard radiologic examination. The newest methods available claim to be able to ascertain the absence of thrombosis, but they have yet to prove their efficiency. We compared the performances of 3 reference ELISA methods (D-DI Asserachrom™ Stago, D-dimer Enzygnost™ Behring and Dimertest GOLD EIA™ Agen), 5 recent rapid methods (VIDAS D-Dimer™ bioMérieux, Instant IA™ Stago, Simplired™ Agen, Nycocard D-dimer™ Nycomed and Accuclot D-Dimer™ Sigma Diagnostics) and two routine latex methods (Dimertest™ American Diagnostica and FDP-Slidex™ bioMérieux) in 100 patients. One of the rapid quantitative methods was demonstrated to have a level of efficiency comparable to that of ELISA methods. Finally, the cost and efficiency of different strategies were evaluated, the association of a routine latex method with the VIDAS D-Dimer™ bioMérieux being proven to be the most efficient.

 

  • References

  • 1 Bounameaux H, de Moerloose P, Perrier A, Reber G. Plasma measurement of D-dimer as diagnostic aid in suspected venous thromboembolism: an overview.. Thromb Haemost 1994; 71: 1-6.
    PubMedGoogle Scholar
  • 2 Elias A, Apter I, Huc B, Chalé JJ, Nguyen F, Cambus JP, Boccalon H, Boneu B. D-dimer test and diagnosis of deep vein thrombosis: a comparative study of 7 assays.. Thromb Haemost 1996; 76: 518-22.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Janssen MCH, Heebels AE, de Metz M, Verbruggen H, Wollersheim H, Janssen S, Schuurmans MMJ, Novakova IRO. Reliability of five rapid D-dimer assays compared to ELISA in the exclusion of deep venous thrombosis.. Thromb Haemost 1997; 77: 262-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Fermanian J. Mesure of concordance between two observers. The qualitative case.. Rev Epid et Santé Publ. 1984; 32: 140-7.
    PubMedGoogle Scholar
  • 5 van Beek E, van den Ende B, Berkmans RJ, van der Heide Y, Brandjes DPM, Sturk A, ten Cate JW. A comparative analysis of D-dimer assays in patients with clinically suspected pulmonary embolism.. Thromb Haemost 1993; 70: 408-13.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 van Beek EJR, Schenk BE, Michel BC, van den Ende B, Brandjes DPM, van der Heide Y, Brandjes DPM. The role of plasma D-dimer concentration in the exclusion of pulmonary embolism.. Br J Haematol 1996; 92: 725-32.
    CrossrefPubMedGoogle Scholar
  • 7 De Merloose P, Desmarais S, Bounameaux H, Reber G, Perrier A, Dupuy G, Pittet JL. Contribution of a new, rapid, individual and quantitative automated D-dimer ELISA to exclude Pulmonary embolism.. Thromb Haemost 1996; 75: 11-3.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 D’Angelo A, D’Alessadro G, Tomassini L, Pittet JL, Dupuy G, Crippa L. Evaluation of a new rapid quantitative D-dimer assay in patients with clinically suspected deep venous thrombosis.. Thromb Haemost 1996; 75: 412-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Pittet JL, de Moerloose P, Reber G, Durand C, Villard C, Piga N, Rolland D, Comby S, Dupuy G. VIDAS® D-dimer: fast quantitative ELISA for measuring D-dimer in plasma.. Clinical Chemistry 1996; 42: 410-5.
    PubMedGoogle Scholar
  • 10 Wells PS, Brill Edwards P, Stevens P, Panju A, Patel A, Douketis E, Massicotte MP, Hirsh J, Weitz JI, Kearon C, Ginsberg JS. A novel and rapid whole blood assay for D-dimer in patients with clinically suspected deep vein thrombosis.. Circulation 1995; 91: 2184-7.
    CrossrefPubMedGoogle Scholar
  • 11 Charles LA, Edwards T, Macik BG. Evaluation of sensitivity and specificity of six D-dimer latex assays.. Arch Pathol Lab Med 1994; 118: 1102-5.
    PubMedGoogle Scholar
  • 12 Raimondi P, Bongard O, de Moerloose P, Reber G, Waldvogel F, Bounameaux H. D-dimer plasma concentration in various clinical conditions: implication for the use of this test in the diagnostic approach of venous thromboembolism.. Thromb Res 1993; 69: 125-30.
    CrossrefPubMedGoogle Scholar
  • 13 de Moerloose P, Minazio P, Reber G, Perrier A, Bounameaux H. D-dimer determination to exclude pulmonary embolism: a two step approach using latex assay as a screening tool.. Thromb Haemost 1994; 72: 89-91.
    PubMedGoogle Scholar