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Thromb Haemost 1999; 81(03): 349-352
DOI: 10.1055/s-0037-1614475
Review Article
Schattauer GmbH

Prothrombotic Genetic Risk Factors and the Occurrence of Gestational Hypertension with or without Proteinuria[*]

Elvira Grandone
1   From the Arteriosclerosis and Thrombosis Unit and Obstetrics and Gynecology Division, I.R.C.C.S. ”Casa Sollievo della Sofferenza“, S. Giovanni Rotondo (FG)
,
Maurizio Margaglione
1   From the Arteriosclerosis and Thrombosis Unit and Obstetrics and Gynecology Division, I.R.C.C.S. ”Casa Sollievo della Sofferenza“, S. Giovanni Rotondo (FG)
,
Donatella Colaizzo
1   From the Arteriosclerosis and Thrombosis Unit and Obstetrics and Gynecology Division, I.R.C.C.S. ”Casa Sollievo della Sofferenza“, S. Giovanni Rotondo (FG)
,
Giuseppe Cappucci
1   From the Arteriosclerosis and Thrombosis Unit and Obstetrics and Gynecology Division, I.R.C.C.S. ”Casa Sollievo della Sofferenza“, S. Giovanni Rotondo (FG)
,
Natale Sciannamé
1   From the Arteriosclerosis and Thrombosis Unit and Obstetrics and Gynecology Division, I.R.C.C.S. ”Casa Sollievo della Sofferenza“, S. Giovanni Rotondo (FG)
,
Sergio Montanaro
1   From the Arteriosclerosis and Thrombosis Unit and Obstetrics and Gynecology Division, I.R.C.C.S. ”Casa Sollievo della Sofferenza“, S. Giovanni Rotondo (FG)
,
Dario Paladini
2   Obstetrics and Gynecology Department, Università Federico II, Naples
,
Pasquale Martinelli
2   Obstetrics and Gynecology Department, Università Federico II, Naples
,
Giovanni Di Minno
3   Institute of Internal Medicine and Geriatrics, Palermo, Italy
› Author Affiliations
Further Information

Publication History

Received26 May 1998

Accepted after resubmission09 December 1998

Publication Date:
09 December 2017 (online)

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Summary

Gestational hypertension with or without proteinuria is a multi-factorial disease in which the presence of a hypercoagulable state has been suggested. The prothrombin G20210A, the Factor V (FV) Leiden mutations, and the C677T 5-10 methylenetethrahydrofolate reductase (MTHFR) polymorphism were investigated in 140 women with gestational hypertension and in 216 normotensive women from Southern Italy. Nine controls (4.1%) and 16 cases (11.4%; OR: 2.96, 95% CI: 1.27-6.91) carried the prothrombin A20210 allele. FV Leiden mutation was observed in 4 controls (1.8%) and 11 cases (7.9%; OR: 4.53, 95% CI: 1.41-14.53). The TT MTHFR genotype was found in 36 controls (16.6%) and 34 cases (24.4%; OR: 1.61, 95%CI: 0.96-2.74).

The impact of potential confounding variables was evaluated using a logistic regression analysis. Nulliparity, Factor V Leiden and prothrombin A20210 carrier status resulted to be independent risk factors of having gestational hypertension with or without proteinuria. Imbalance of haemostasis, through prothrombotic genetic factors, may predispose to the occurrence of gestational hypertension.

* The financial support of Telethon-Italy (Grant no. E. C 561) is gratefully acknowledged.


 

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