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Thromb Haemost 1998; 79(03): 517-519
DOI: 10.1055/s-0037-1614936
Review Articles
Schattauer GmbH

Feasibility Study of Catheter-directed Thrombolysis with Recombinant Staphylokinase in Deep Venous Thrombosis

Stephane Heymans
1   Center for Molecular and Vascular Biology
,
Raymond Verhaeghe
2   Center for Vascular Pathology
,
Luc Stockx
3   Department of Radiology, University of Leuven, Belgium
,
Désiré Collen
1   Center for Molecular and Vascular Biology
› Author Affiliations
Further Information

Publication History

Received 19 September 1997

Accepted after revision 07 November 1997

Publication Date:
07 December 2017 (online)

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Summary

The feasibility of catheter-directed thrombolysis with recombinant staphylokinase was evaluated in six selected patients with deep vein thrombosis. The patients underwent intrathrombus infusion of recombinant staphylokinase (2 mg bolus followed by a continuous infusion of 1 mg/h). Heparin was given via the catheter as a bolus (5000 U) and as a continuous infusion (1000 U/h). Complete lyis was obtained in five patients and partial lysis in one patient. Complications consisted of minor bleeding in four subjects. Symptomatic reocclusion occurred in one. Debulking of the thrombus mass by a high speed rotating impeller (n = 1) and stenting (n = 3) were used as additional interventions. An underlying anatomical abnormality was present in two patients. Long term follow up revealed normal patency in all patients and normal valve function in four patients. Symptomatic venous insufficiency with valve dysfunction was present in the two with a second thrombotic episode.

Thus catheter-directed infusion of recombinant staphylokinase in patients with deep vein thrombosis appears feasible and may be associated with a high frequency of thrombolysis. Larger studies to define the clinical benefit of this treatment appear to be warranted.

 

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