High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease

Thromb Haemost 2005; 94(04): 886-887
DOI: 10.1055/s-0037-1615584

Letters to the Editor

Schattauer GmbH

Boris Aleil

¹Institut National de la Santé et de la Recherche Médicale U.311, Etablissement Français du Sang – Alsace, Strasbourg, France

,

Nicolas Meyer

²Département de Santé Publique et de Biostatistique, Hôpital Civil, Strasbourg, France

,

Jean-Pierre Cazenave

¹Institut National de la Santé et de la Recherche Médicale U.311, Etablissement Français du Sang – Alsace, Strasbourg, France

,

Jean-Marie Mossard

³Service de Cardiologie, Hôpital Civil, Strasbourg, France

,

Christian Gachet

¹Institut National de la Santé et de la Recherche Médicale U.311, Etablissement Français du Sang – Alsace, Strasbourg, France

References
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2 Matetzky S, Shenkman B, Guetta V. et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004; 109: 3171-5.
3 Geiger J, Brich J, Honig-Liedl P. et al. Specific impairment of human platelet P2Y(AC) ADP receptor mediated signaling by the antiplatelet drug clopidogrel. Arterioscler Thromb Vasc Biol 1999; 19: 2007-11.
4 Schwarz UR, Geiger J, Walter U. et al. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets–definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost 1999; 82: 1145-52.
5 Grossmann R, Sokolova O, Schnurr A. et al. Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thromb Haemost 2004; 92: 1201-6.
6 Aleil B, Ravanat C, Cazenave JP. et al. Flow cytometric analysis of intra-platelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005; 3: 85-92.