Download PDF
Thromb Haemost 2005; 94(04): 886-887
DOI: 10.1055/s-0037-1615584
Letters to the Editor
Schattauer GmbH

High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease

Boris Aleil
1   Institut National de la Santé et de la Recherche Médicale U.311, Etablissement Français du Sang – Alsace, Strasbourg, France
,
Nicolas Meyer
2   Département de Santé Publique et de Biostatistique, Hôpital Civil, Strasbourg, France
,
Jean-Pierre Cazenave
1   Institut National de la Santé et de la Recherche Médicale U.311, Etablissement Français du Sang – Alsace, Strasbourg, France
,
Jean-Marie Mossard
3   Service de Cardiologie, Hôpital Civil, Strasbourg, France
,
Christian Gachet
1   Institut National de la Santé et de la Recherche Médicale U.311, Etablissement Français du Sang – Alsace, Strasbourg, France
› Author AffiliationsFinancial support: This work was supported by ARMESA.
Further Information

Publication History

Received31 March 2005

Accepted after resubmission12 July 2005

Publication Date:
11 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Serebruany VL, Steinhubl SR, Berger PB. et al. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 2005; 45: 246-51.
    CrossrefPubMedSearch in Google Scholar
  • 2 Matetzky S, Shenkman B, Guetta V. et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004; 109: 3171-5.
    CrossrefPubMedSearch in Google Scholar
  • 3 Geiger J, Brich J, Honig-Liedl P. et al. Specific impairment of human platelet P2Y(AC) ADP receptor mediated signaling by the antiplatelet drug clopidogrel. Arterioscler Thromb Vasc Biol 1999; 19: 2007-11.
    CrossrefPubMedSearch in Google Scholar
  • 4 Schwarz UR, Geiger J, Walter U. et al. Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets–definition and detection of ticlopidine/clopidogrel effects. Thromb Haemost 1999; 82: 1145-52.
    Thieme ConnectPubMedSearch in Google Scholar
  • 5 Grossmann R, Sokolova O, Schnurr A. et al. Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thromb Haemost 2004; 92: 1201-6.
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 Aleil B, Ravanat C, Cazenave JP. et al. Flow cytometric analysis of intra-platelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005; 3: 85-92.
    CrossrefPubMedSearch in Google Scholar