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Nervenheilkunde 2010; 29(11): 758-760
DOI: 10.1055/s-0038-1628836
Kognitive Störungen
Schattauer GmbH

Bildgebende Verfahren in der Diagnostik von Demenzerkrankungen

Brain imaging in the diagnostic process of dementia
F Jessen
1   Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn
› Institutsangaben
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Publikationsverlauf

Eingegangen am: 21. Juni 2010

angenommen am: 16. August 2010

Publikationsdatum:
31. Januar 2018 (online)

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Zusammenfassung

Die zerebrale Bildgebung hat in der ätiologischen Diagnostik von Demenzerkrankungen die Funktion z. B. chirurgisch behandelbare Ursachen einer Demenz aufzudecken. Zusätzlich trägt sie zur Differenzialdiagnose von primären Demenzerkrankungen bei. Neurodegenerative Erkrankungen sind durch typische Atrophiemuster gekennzeichnet. Vaskuläre Läsionen können sensitiv mit der MRT erfasst werden. Zahlreiche neue MRT-Verfahren befinden sich in der klinischen Entwicklung. Als nuklearmedizinisches Verfahren ist insbesondere die 18F-Fluordesoxyglukose (FDG)-PET wertvoll. Die zukünftige klinische Relevanz von Amyloid-PET wird mit großer Wahrscheinlichkeit sehr hoch sein.

Summary

In the diagnostic process of dementia brain imaging is needed to detect causes of dementia that may be reversible by for example surgical interventions. Also brain imaging helps in differentiating primary causes of dementia. Neurodegenerative disorders are characterized by typical patterns of atrophy. Vascular damage can be detected sensitively with MRI. Among nuclear medicine techniques, 18F-Fluordesoxyglucose (FDG)-PET is particularly valuable. The importance of amyloid PET in clinical practice in the future will be high.

Schlüsselwörter

Demenz - Alzheimer - MRT - PET

Keywords

Dementia - Alzheimer’s disease - MRI - PET
 

  • Literatur

  • 1 Cordonnier C. et al. Prevalence and severity of microbleeds in a memory clinic setting. Neurology 2006; 66 (09) 1356-1360.
    CrossrefPubMedGoogle Scholar
  • 2 Dormont D, Seidenwurm D. J. Dementia and movement disorders. AJNR Am J Neuroradiol 2008; 29 (01) 204-206.
    PubMedGoogle Scholar
  • 3 Engler H. et al. Two-year follow-up of amyloid deposition in patients with Alzheimer’s disease. Brain 2006; 129 (Pt 11): 2856-2866.
    CrossrefPubMedGoogle Scholar
  • 4 Fazekas F. et al. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 1987; 149 (02) 351-356.
    CrossrefPubMedGoogle Scholar
  • 5 Gifford D. R, Holloway R. G, Vickrey B. G. Systematic review of clinical prediction rules for neuroimaging in the evaluation of dementia. Arch Intern Med 2000; 160 (18) 2855-2862.
    CrossrefPubMedGoogle Scholar
  • 6 Gold G. et al. Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach. J Neurol Sci 2007; 257 (1–2): 17-22.
    CrossrefPubMedGoogle Scholar
  • 7 Hejl A, Hogh P, Waldemar G. Potentially reversible conditions in 1000 consecutive memory clinic patients. J Neurol Neurosurg Psychiatry 2002; 73 (04) 390-394.
    CrossrefPubMedGoogle Scholar
  • 8 Herholz K, Carter S. F, Jones M. Positron emission tomography imaging in dementia. Br J Radiol 2007; 80 (02) S160-167.
    CrossrefPubMedGoogle Scholar
  • 9 Jack C. R. et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol 2010; 09 (01) 119-128.
    CrossrefPubMedGoogle Scholar
  • 10 Jellinger K. A, Attems J. Neuropathological evaluation of mixed dementia. J Neurol Sci 2007; 257 (1–2): 80-87.
    CrossrefPubMedGoogle Scholar
  • 11 Korf E. S. et al. Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology 2004; 63 (01) 94-100.
    CrossrefPubMedGoogle Scholar
  • 12 Lindberg O. et al. Cortical morphometric subclassification of frontotemporal lobar degeneration. AJNR Am J Neuroradiol 2009; 30 (06) 1233-1239.
    CrossrefPubMedGoogle Scholar
  • 13 McKeith I. et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol 2007; 06 (04) 305-313.
    CrossrefPubMedGoogle Scholar
  • 14 Morris J. C. et al. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Arch Neurol 2009; 66 (12) 1469-1475.
    PubMedGoogle Scholar
  • 15 Mosconi L. et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. J Nucl Med 2008; 49 (03) 390-398.
    CrossrefPubMedGoogle Scholar
  • 16 Patterson C. et al. The recognition, assessment and management of dementing disorders: conclusions from the Canadian Consensus Conference on Dementia. Can J Neurol Sci 2001; 28 Suppl (Suppl. 01) S3-16.
    CrossrefPubMedGoogle Scholar
  • 17 Scheltens P. et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993; 114 (01) 7-12.
    CrossrefPubMedGoogle Scholar
  • 18 Scheltens P. et al. Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol 1995; 242 (09) 557-560.
    CrossrefPubMedGoogle Scholar
  • 19 Wahlund L. O. et al. Visual assessment of medical temporal lobe atrophy in demented and healthy control subjects: correlation with volumetry. Psychiatry Res 1999; 90 (03) 193-199.
    CrossrefPubMedGoogle Scholar
  • 20 Watson R, Blamire A. M, O’Brien J. T. Magnetic Resonance Imaging in Lewy Body Dementias. Dement Geriatr Cogn Disord 2009; 28 (06) 493-506.
    CrossrefPubMedGoogle Scholar