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Methods Inf Med 2004; 43(03): 268-272
DOI: 10.1055/s-0038-1633867
Original Article
Schattauer GmbH

Physicians’ Choice in Using Internet and Fax for Patient Recruitment and Follow-up in a Randomized Controlled Trial

M. Rahman
1   Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
S. Morita
1   Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
T. Fukui
2   Department of General Medicine and Clinical Epidemiologiy, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
J. Sakamoto
1   Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Kyoto, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
05 February 2018 (online)

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Summary

Objective: To examine the physicians’ preference between Web and fax-based remote data entry (RDE) system for an ongoing randomized controlled trial (RCT) in Japan.

Methods: We conducted a survey among all the collaborating physicians (n = 512) of the CASE-J (Candesartan Antihypertensive Survival Evaluation in Japan) trial, who have been recruiting patients and sending follow-up data using the Web or a fax-based RDE system. The survey instrument assessed physicians’ choice between Web and fax-based RDE systems, their practice pattern, and attitudes towards these two modalities.

Results: A total of 448 (87.5%) responses were received. The proportions of physicians who used Web, fax, and the combination of these two were 45.9%, 33.3% and 20.8%, respectively. Multivariate logistic regression analyses revealed that physicians 55 years or younger [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.3] and regular users of computers (OR = 4.2, 95% CI = 2.1-8.2) were more likely to use the Web-based RDE system.

Conclusions: This information would be useful in designing an RCT with a Web-based RDE system in Japan and abroad.

Keywords

Randomized controlled trial - Web - fax - physicians’ choice - patient recruitment
 

  • References

  • 1 Marks R, Bristol H, Conlon M, Pepine CJ. Enhancing clinical trials on the internet: lessons from INVEST. Clin Cardiol 2001; 24 (Suppl. 11) Suppl V17-23.
    PubMedGoogle Scholar
  • 2 Rangel SJ, Narasimhan B, Geraghty N, Moss RL. Development of an internet-based protocol to facilitate randomized clinical trials in pediatric surgery. J Pediatr Surg 2002; 37 (07) 990-4.
    CrossrefPubMedGoogle Scholar
  • 3 Pepine CJ, Handberg-Thurmond E, Marks RG, Conlon M, Cooper-DeHoff R, Volkers P, Zellig P. Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension. J Am Coll Cardiol 1998; 32 (05) 1228-37.
    CrossrefPubMedGoogle Scholar
  • 4 Dorman K, Saade GR, Smith H, Moise Jr KJ. Use of the World Wide Web in research: randomization in a multicenter clinical trial of treatment for twin-twin transfusion syndrome. Obstet Gynecol 2000; 96 (04) 636-9.
    PubMedGoogle Scholar
  • 5 Kelly MA, Oldham J. The Internet and randomised controlled trials. Int J Med Inf 1997; 47 1-2 91-9.
    CrossrefPubMedGoogle Scholar
  • 6 Santoro E, Nicolis E, Franzosi MG, Tognoni G. Internet for clinical trials: past, present, and future. Control Clin Trials 1999; 20 (02) 194-201.
    CrossrefPubMedGoogle Scholar
  • 7 Kuchenbecker J, Dick HB, Schmitz K, Behrens-Baumann W. Use of internet technologies for data acquisition in large clinical trials. Telemed J E Health 2001; 7 (01) 73-6.
    CrossrefPubMedGoogle Scholar
  • 8 Sippel H, Eich HP, Ohmann C. Data collection in multi-center clinical trials via Internet. A generic system in Java. Medinfo 1998; 9 Pt 1 93-7.
    PubMedGoogle Scholar
  • 9 Afrin LB, Kuppuswamy V, Slater B, Stuart RK. Electronic clinical trial protocol distribution via the World-Wide Web: a prototype for reducing costs and errors, improving accrual, and saving trees. JAMIA 1997; 4 (01) 25-35.
    PubMedGoogle Scholar
  • 10 Kiuchi T, Ohashi Y, Konishi M, Bandai Y, Kosuge T, Kakizoe T. A World Wide Web-based user interface for a data management system for use in multi-institutional clinical trials – development and experimental operation of an automated patient registration and random allocation system. Control Clin Trials 1996; 17 (06) 476-93.
    CrossrefPubMedGoogle Scholar
  • 11 Higgins SB, Jiang K, Plummer Jr. WD, Edens TR, Stroud MJ, Swindell BB, Wheeler AP, Bernard GR. Pivot/Remote: a distributed database for remote data entry in multi-center clinical trials. Medinfo 1995; 8 Pt 2 1097
    PubMedGoogle Scholar
  • 12 Fukui T, Rahman M, Hayashi K. et al. Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial of cardiovascular events in high-risk hypertensive patients: Rationale, design and methods. Hypertens Res 2003; 26 (12) 979-90.
    CrossrefPubMedGoogle Scholar
  • 13 STATA statistical software version 7.0 (Intercooled). STATA Corporation. College Station, Texas, USA.
    PubMedGoogle Scholar
  • 14 Anonymous. Survey on physicians, dentists, and pharmacist. Journal of Health and Welfare Statistics. Health and Welfare Statistical Association 2002, Volume 9, No. 9, p. 472 (in Japanese).
    PubMedGoogle Scholar
  • 15 Anonymous. Health care manpower. Journal of Health and Welfare Statistics. Health and Welfare Statistical Association 2002; Volume 9 No (09) 170-83. (in Japanese)
    PubMedGoogle Scholar