Medical Informatics in Medical Research

C. H. O. Olola; M. A. Missinou; S. Issifou; E. Anane-Sarpong; I. Abubakar; J. N. Gandi; M. Chagomerana; M. Pinder; T. Agbenyega; P. G. Kremsner; C. R. J. C. Newton; D. Wypij; T. E. Taylor; on Behalf of the SMAC Network

doi:10.1055/s-0038-1634108

Methods of Information in Medicine, Inhaltsverzeichnis

Methods Inf Med 2006; 45(05): 483-491
DOI: 10.1055/s-0038-1634108

Original Article

Schattauer GmbH

Medical Informatics in Medical Research

The Severe Malaria in African Children (SMAC) Network’s Experience

C. H. O. Olola

¹Kenya Medical Research Institute, Centre for Geographic Medicine Research – Coast (CGMRC), Kenya

,

M. A. Missinou

²Albert Schweitzer Hospital, Gabon, and Department of Parasitology, Institute of Tropical Medicine, University of Tuebingen, Germany

,

S. Issifou

²Albert Schweitzer Hospital, Gabon, and Department of Parasitology, Institute of Tropical Medicine, University of Tuebingen, Germany

,

E. Anane-Sarpong

³Department of Physiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi and Komfo Anokye Teaching Hospital, Ghana

,

I. Abubakar

⁴Medical Research Council and Royal Victoria Teaching Hospital, Gambia

,

J. N. Gandi

¹Kenya Medical Research Institute, Centre for Geographic Medicine Research – Coast (CGMRC), Kenya

,

M. Chagomerana

⁵Blantyre Malaria Project, Malawi

,

M. Pinder

⁴Medical Research Council and Royal Victoria Teaching Hospital, Gambia

,

T. Agbenyega

³Department of Physiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi and Komfo Anokye Teaching Hospital, Ghana

,

P. G. Kremsner

²Albert Schweitzer Hospital, Gabon, and Department of Parasitology, Institute of Tropical Medicine, University of Tuebingen, Germany

,

C. R. J. C. Newton

¹Kenya Medical Research Institute, Centre for Geographic Medicine Research – Coast (CGMRC), Kenya

,

D. Wypij

⁶Children’s Hospital Boston, Clinical Research Program (CRP), Boston, MA, USA

,

T. E. Taylor

⁵Blantyre Malaria Project, Malawi

⁷Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, USA

› Institutsangaben

on Behalf of the SMAC Network

Abstract

Summary

Objectives: Computers are widely used for data management in clinical trials in the developed coutries, unlike in developing countries. Dependable systems are vital for data management, and medical decision making in clinical research. Monitoring and evaluation of data management is critical.

In this paper we describe database structures and procedures of systems used to implement, coordinate, and sustain data management in Africa. We outline major lessons, challenges and successes achieved, and recommendations to improve medical informatics application in biomedical research in sub-Saharan Africa.

Methods: A consortium of experienced research units at five sites in Africa in studying children with disease formed a new clinical trials network, Severe Malaria in African Children. In December 2000, the network introduced an observational study involving these hospital-based sites. After prototyping, relational database management systems were implemented for data entry and verification, data submission and quality assurance monitoring.

Results: Between 2000 and 2005, 25,858 patients were enrolled. Failure to meet data submission deadline and data entry errors correlated positively (correlation coefficient, r = 0.82), with more errors occurring when data was submitted late. Data submission lateness correlated inversely with hospital admissions (r = –0.62).

Conclusions: Developing and sustaining dependable DBMS, ongoing modifications to optimize data management is crucial for clinical studies. Monitoring and communication systems are vital in multi-center networks for good data management. Data timeliness is associated with data quality and hospital admissions.

Keywords

Medical informatics computing - malaria - multi-center studies

Volltext

Referenzen

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