Multistate Survival Analysis: An Application in Breast Cancer

Summary

The extension of the proportional hazard model of Cox for survival data allows the consideration of transition times between events of interest (e.g., response, relapse, progression, etc.) and of competing risks. This paper applies these new models to a breast cancer study and gives some general remarks for the proceeding.

Die Erweiterung des proportionalen Hazard-Modells für Überlebensdaten von Cox erlaubt die Berücksichtigung von Übergängen zwischen interessierenden Ereignissen (wie z.B. Ansprechen auf die Therapie, Rückfälle, Krankheitsprogression) und von konkurrierenden Risiken. Die vorliegende Arbeit wendet die neuen Modelle am Beispiel einer klinischen Brustkrebsstudie an und gibt einen allgemeinen Kommentar dazu.

Key-Words:

Extended Proportional Hazard Model - Multistate Survival Analysis - Competing Risks - Breast Cancer

Schlüssel-Wörter:

Erweitertes Cox-Modell - Überlebensanalyse mit mehreren Übergängen - konkurrierende Risiken - Brustkrebs

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