Biochemical and Molecular Aspects of the Coagulation Cascade

Earl W Davie

doi:10.1055/s-0038-1642645

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(01): 001-006
DOI: 10.1055/s-0038-1642645

Special Colloquium

Schattauer GmbH Stuttgart

Biochemical and Molecular Aspects of the Coagulation Cascade

Earl W Davie

Department of Biochemistry, University of Washington, Seattle, WA, USA

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References

References
1 Ratnoff OD, Davie EW. The activation of Christmas factor (factor IX) by activated plasma thromboplastin antecedent (activated factor XI). Biochemistry 1962; 1: 677-685
2 Seegers WH, McClaughry RI, Fahey JL. Some properties of purified prothrombin and its activation with sodium citrate. Blood 1950; 5: 421
3 Fujikawa K, Coan MH, Enfield DL, Titani K, Ericsson LH, Davie EW. A comparison of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor). Proc Natl Acad Sci USA 1974; 71 (02) 427-430
4 Stenflo J, Femlund P, Egan W, Roepstorff P. Vitamin K-dependent modifications of glutamic acid residues in prothrombin. Proc Natl Acad Sci USA 1974; 71: 2730-2733
5 Magnusson S, Petersen TE, Sottrup-Jensen L, Claeys H. Complete Primary Structure of Prothrombin: Isolation, Structure and Reactivity of Ten Carboxylated Glutamic Acid Residues and Regulation of Prothrombin Activation by Thrombin. In: Proteases and Biological Control. Reich E, Rifkin DB, Shaw E. eds. Cold Spring Harbor Laboratory; 1975: 123-149
6 Nelsestuen GL, Zytkovicz TH, Howard JB. The mode of action of vitamin K. J Biol Chem 1974; 249: 6347-6350
7 Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science 1964; 145: 1310-1312
8 MacFarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 1964; 202: 498-499
9 Bach R, Nemerson Y, Konigsberg W. Purification and characterization of bovine tissue factor. J Biol Chem 1981; 256: 8324-8331
10 Morrissey JH, Fair DS, Edgington TS. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell 1987; 50: 129-135
11 Spicer EK, Horton B, Bloem L, Bach R, Williams KR, Guha A, Kraus J, Lin TC, Nemerson Y, Konigsberg WH. Isolation of cDNA clones coding for human tissue factor, primary structure of the protein and cDNA. Proc Natl Acad Sci USA 1987; 84: 5148-5152
12 Scarpati EM, Wen D, Broze Jr G, Miletich JP, Flandermeyer RR, Siegel NR, Sadler JE. Human tissue factor: cDNA sequence and chromosome localization of the gene. Biochemistry 1987; 26: 5234-5238
13 Fisher KL, Gorman CM, Vehar GA, O’Brien DP, Lawn RM. Cloning and expression of human tissue factor cDNA. Thromb Res 1987; 48: 89-99
14 Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 1991; 30: 10363-10370
15 Nemerson Y, Repke D. Tissue factor accelerates the activation of coagulation factor VII: the role of a bifunctional coagulation cofactor. Thromb Res 1985; 40: 351-358
16 Rao LVM, Rapaport SI. Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation. Proc Natl Acad Sci USA 1988; 85: 6687-6691
17 Sakai T, Lund-Hansen T, Paborsky L, Pedersen AH, Kisiel W. Binding of human factors VII and VIIa to a human bladder carcinoma cell line (J82). Implications for the initiation of the extrinsic pathway of blood coagulation. J Biol Chem 1989; 264: 9980-9988
18 Hagen FS, Gray CL, O’Hara P, Grant FJ, Saari GC, Woodbury RG, Hart CE, Insley M, Kisiel W, Kurachi K, Davie EW. Characterization of a cDNA coding for human factor VII. Proc Natl Acad Sci USA 1986; 83: 2412-2416
19 Broze Jr GJ, Miletich JP. Characterization of the inhibition of tissue factor in serum. Blood 1987; 69: 150-155
20 Rao LVM, Rapaport SI. Studies of a mechanism inhibiting the initiation of extrinsic pathway of coagulation. Blood 1987; 69: 645-651
21 Rosenberg RD, Damus PS. The purification and mechanism of action of human antithrombin/heparin cofactor. J Biol Chem 1973; 248: 6490-6505
22 Kurachi K, Fujikawa K, Schmer G, Davie EW. Inhibition of bovine factor IXa and factor Xa by antithrombin III. Biochemistry 1976; 15: 373-377
23 Kurachi K, Davie EW. Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor). Biochemistry 1977; 16: 5831-5839
24 Tollefsen DM, Majerus PW, Blank MK. Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma. J Biol Chem 1982; 257: 2162-2169
25 Sottrup-Jensen L. a₂-Macroglobulin and related thiol ester plasma proteins. In: The Plasma Proteins: Structure, Function, and Genetic Control Vol.5. Putnam FW. ed. Academic Press; New York, NY: 1987: 191-291
26 Suzuki K, Nishioka J, Hashimoto S. Protein C inhibitor. Purification from human plasma and characterization. J Biol Chem 1983; 258: 163-168
27 Heeb MJ, Griffin JH. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. J Biol Chem 1988; 263: 11613-11616
28 Stenflo J. A new vitamin K-dependent protein. J Biol Chem 1976; 251: 355-363
29 Kisiel W. Human plasma protein C. Isolation, characterization and mechanism of activation by a-thrombin. J Clin Invest 1979; 64: 761-769
30 Vehar G, Davie EW. Preparation and properties of bovine factor VIII. Biochemistry 1980; 19: 401-410
31 Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA 1981; 78: 2249-2252
32 Esmon CT, Esmon NL, Harris KW. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem 1982; 257: 7944-7947
33 DiScipio RG, Davie EW. Characterization of protein S, a c-carboxyglutamic acid containing protein from bovine and human plasma. Biochemistry 1979; 18: 899-904
34 DiScipio RG, Hermodson MA, Yates SG, Davie EW. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S. Biochemistry 1977; 16: 698-706
35 Walker FJ. Regulation of activated protein C by a new protein. J Biol Chem 1980; 255: 5521-5524
36 Walker FJ. Regulation of activated protein C by protein S: the role of phospholipid in factor Va inactivation. J Biol Chem 1981; 256: 11128-11131
37 Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C. Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008
38 Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 300: 517-522
39 Dahlback B, Hildebrand B. Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Nad Acad Sci USA 1994; 91: 1396-1400
40 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature (Lond.) 1994; 369: 64-67
41 Griffin JH, Evatt B, Widerman C, Femanadez JA. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood 1993; 82: 1989-1993
42 Rixon MW, Chan WY, Davie EW, Chung DW. Characterization of a cDNA coding for the a chain of human fribrinogen. Biochemistry 1983; 22: 3237-3244
43 Chung DW, Que BG, Rixon MW, Mace Jr M, Davie EW. Characterization of the cDNA and genomic DNA for the b chain of human fibrinogen. Biochemistry 1983; 22: 3244-3250
44 Chung DW, Chan WY, Davie EW. Characterization of a cDNA coding for the c chain of human fibrinogen. Biochemistry 1983; 22: 3250-3256
45 Crabtree GR, Kant JA. Coordinate accumulation of the mRNAs for the a, b, and c chains of rat fibrinogen following defibrination. J Biol Chem 1982; 257: 7277-7279
46 MacGillivray RTA, Degen SJF, Chandra T, Woo SLC, Davie EW. Cloning and analysis of a cDNA coding for bovine prothrombin. Proc Natl Acad Sci USA 1980; 77: 5153-5157
47 Degen SJF, MacGillivray RTA, Davie EW. Characterization of the cDNA and gene coding for human prothrombin. Biochemistry 1983; 22: 2087-2097
48 Gitschier J, Wood WI, Goralka TM, Wion KL, Chen EY, Eaton DH, Vehar GA, Capon DJ, Lawn RM. Characterization of the human factor VIII gene. Nature 1984; 312: 326-330
49 Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, Kaufman RJ, Brown E, Shoemaker C, Orr EC, Amphlett GW, Foster B, Coe ML, Knutson GJ, Fass DN, Hewick RM. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 1984; 312: 342-347
50 Kurachi K, Davie EW. Isolation and characterization of a cDNA coding for human factor IX. Proc Natl Acad Sci USA 1982; 79: 6461-6464
51 Yoshitake S, Schach BG, Foster DC, Davie EW, Kurachi K. Nucleotide sequence of the gene for human factor IX (antihemophilic factor B). Biochemistry 1985; 24: 3736-3750
52 Anson DS, Choo KH, Rees DJG, Giannelli F, Gould K, Huddleston JA, Brownlee GG. The gene structure of human anti-haemophilic factor IX. EMBOJ 1984; 3: 1053-1060
53 Leytus SP, Chung DW, Kisiel W, Kurachi K, Davie EW. Characterization of a cDNA coding for human factor X. Proc Natl Acad Sci USA 1984; 82: 3699-3702
54 Fung MR, Hay CW, MacGillivray RTA. Characterization of an almost full-length cDNA coding for human blood coagulation factor X. Proc Natl Acad Sci USA 1985; 82: 3591-3595
55 Hedner U, Davie EW. Introduction to Hemostasis and the Vitamin K-Dependent Coagulation Factors. In: The Metabolic Basis of Inherited Disease. Scriver CR, Beaudet AL, Sly WS, Valle D. eds. McGraw-Hill, Inc.; New York, NY: 1989: 2107-2134
56 Foster DC, Rudinski MS, Schach BG, Berkner KL, Kumar AA, Hagen FS, Sprecher CA, Insley MY, Davie EW. Propeptide of human protein C is necessary for c-carboxylation. Biochemistry 1987; 26: 7003-7011
57 Jorgensen MJ, Cantor AB, Furie BC, Brown CL, Shoemaker CB, Furie B. Recognition site-directed vitamin K-dependent c-carboxylation resides on the propeptide of factor IX. Cell 1987; 48: 185-191
58 Thompson AR. Molecular biology of the hemophilias. Prog Hemost Thromb 1991; 10: 175-214
59 Giannelli F, Green PM, High KA, Sommer S, Lillicrap DP, Ludwig M, Olek K, Reitsma PH, Goossens M, Yoshioka A, Brownlee GG. Haemophilia B: database of point mutations and short additions and deletions-third edition. Nucleic Acids Res (suppl) 1992; 306: 788
60 Huang S, Mulvihill ER, Farrell DH, Chung DW, Davie EW. Biosynthesis of human fibrinogen: subunit interactions and potential intermediates in the assembly. J Biol Chem 1993; 268: 8919-8926
61 Yu S, Sher B, Kudryk B, Redman CM. Intracellular assembly of human fibrinogen. J Biol Chem 1983; 258: 13407-13410
62 Yu S, Sher B, Kudryk B, Redman CM. Fibrinogen precursors. Order of assembly of fibrinogen chains. J Biol Chem 1984; 259: 10574-10581
63 Xu WF, Chung DW, Davie EW. unpublished data
64 Farrell D, Thiagarajan P, Chung DW, Davie EW. Role of fibrinogen a and c chain sites in platelet aggregation. Proc Natl Acad Sci USA 1992; 89: 10729-10732
65 Hawiger J, Timmons S, Kloczewiak M, Strong DD, Doolittle RF. c and a chains of human fibrinogen possess sites reactive with human platelet receptors. Proc Natl Acad Sci USA 1982; 79: 2068-2071
66 Hu CH, Mizuguchi J, Chung DW. unpublished data
67 Morgan JG, Courtois G, Fourel G, Chodosh LA, Campbell L, Evans E, Crabtree GR. Sp1, a CAAT-binding factor, and the adenovirus major late promoter transcription factor interact with functional regions of the c-fibrinogen promoter. Mol Cell Biol 1988; 8: 2628-2637
68 Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR. Interaction of a liver-specific nuclear factor with the fibrinogen and a₁-antitrypsin promoters. Science 1987; 238: 688-692
69 Huber P, Laurent M, Dalmon J. Human b-fibrinogen gene exprssion: upstream sequences involved in its tissue-specific expression and its dexamethasone and interleukin 6 stimulation. J Biol Chem 1990; 265: 5696-5701
70 Kugler W, Wagner U, Ryffel GU. Tissue specificity of liver gene expression: a common liver-specific promoter element. Nucleic Acids Res 1988; 16: 3165-3174
71 Dalmon J, Laurent M, Courtois G. The human b fibrinogen promoter contains a HAF-1-dependent IL-6 responsive element. Mol Cell Biol 1993; 13: 1183-1193
72 Fowlkes DM, Mullis NT, Comeau CM, Crabtree GR. Potential basis for regulation of the coordinately expressed fibrinogen genes: homology in the 5' flanking regions. Proc Natl Acad Sci USA 1984; 81: 2313-2316
73 Chung DW, Harris JE, Davie EW. Nucleotide Sequences of the Three Genes Coding for Human Fibrinogen. In: Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis. Liu CY, Chien S. eds. Plenum Press; New York, NY: 1990: 39-48
74 Crossley M, Ludwig M, Stowell KM, De Vos P, Olek K, Brownlee GG. Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IX promoter. Science 1992; 257: 377-379
75 Reijnen MJ, Sladek FM, Bertina RM, Reitsma PH. Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden. Proc Natl Acad Sci USA 1992; 89: 6300-6303
76 Crossley M, Brownlee GG. Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Nature 1990; 345: 444-446
77 Miao CH, Leytus SP, Chung DW, Davie EW. Liver-specific expression of the gene coding for human factor X, a blood coagulation factor. J Biol Chem 1992; 267: 7395-7401
78 Chow BK-C, Ting V, Tufaro F, MacGillivray RTA. Characterization of a novel liver-specific enhancer in the human prothrombin gene. J Biol Chem 1991; 266: 18927-18933