DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 07 · Volume 74 · 1995 DOI: 10.1055/s-009-45162

Special Colloquium

001
Davie, Earl W: Biochemical and Molecular Aspects of the Coagulation Cascade
007
Rapaport, Samuel I; Rao, L Vijaya Mohan: The Tissue Factor Pathway: How It Has Become a “Prima Ballerina”
018
Caen, Jacques P; Rosa, Jean-Philippe: Platelet-Vessel Wall Interaction: from the Bedside to Molecules
025
Verstraete, Marc: The Fibrinolytic System: from Petri Dishes to Genetic Engineering

Colloquium

The Haemophilias-An Update

036
Evatt, Bruce L: AIDS and Hemophilia - Current Issues
040
Peake, Ian: Molecular Genetics and Counselling in Haemophilia
045
Thompson, Arthur R: Progress Towards Gene Therapy for the Hemophilias

Symposium

Vascular Wall Cells

052
Rosenberg, Robert D: The Absence of the Blood Clotting Regulator Thrombomodulin Causes Embryonic Lethality in Mice Before Development of a Functional Cardiovascular System
058
Pinsky, David J: The Vascular Biology of Heart and Lung Preservation for Transplantation

Natural Inhibitors of Fibrinolysis

066
Deng, Gang; Royle, Gordon; Seiffert, Dietmar; Loskutoff, David J: The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

Special Colloquium

Natural Inhibitors Of fibrinolysis

071
Wiman, Björn: Plasminogen Activator Inhibitor 1 (PAI-1) in Plasma: Its Role in Thrombotic Disease

Symposium

Platelets,Prostaglandins,Lipids,NO

077
Szczeklik, Andrzej: Thrombin Generation in Myocardial Infarction and Hypercholesterolemia: Effects of Aspirin

Colloquium

Natural Inhibitors of Blood Coagulation

081
Aiach, Martine; Gandrille, Sophie; Emmerich, Joseph: A Review of Mutations Causing Deficiencies of Antithrombin, Protein C and Protein S

Natural Inhibitors of Blood Cogulation

090
Broze, George J: Tissue Factor Pathway Inhibitor
094
Bauer, Kenneth A: Management of Patients with Hereditary Defects Predisposing to Thrombosis Including Pregnant Women

Symposium

Thrombolytic Thearpy

101
Marder, Victor J: Thrombolytic Therapy: Overview of Results in Major Vascular Occlusions

Thrombolytic Therapy

106
Samama, M M; Acar, J: Thrombolytic Therapy: Future Issues

Platelet Activation and Signal Transduction

111
Clemetson, Kenneth J: Platelet Activation: Signal Transduction Via Membrane Receptors

Hemorheology

117
Weiss, Harvey J: Flow-Related Platelet Deposition on Subendothelium
123
Grabowski, Eric F; Lam, Frances P: Endothelial Cell Function, Including Tissue Factor Expression, Under Flow Conditions

Thrombin - Bilogical Activities

129
Guillin, Marie-Claude; Bezeaud, Annie; Bouton, Marie-Christine; Jandrot-Perrus, Martine: Thrombin Specificity
134
Hemker, H Coenraad; Béguin, Suzette: Thrombin Generation in Plasma: Its Assessment Via the Endogenous Thrombin Potential

Plenary Lecture

139
Dahlbäck, Björn: New Molecular Insights into the Genetics of Thrombophilia. Resistance to Activated Protein C Caused by Arg506 to Gin Mutation in Factor V as a Pathogenic Risk Factor for Venous Thrombosis
149
Shattil, Sanford J: Function and Regulation of the β3 Integrins in Hemostasis and Vascular Biology
302
Coller, Barry S; Anderson, Keaven; Weisman, Harlan F: New Antiplatelet Agents: Platelet GPIIb/llla Antagonists
309
Dejana, Elisbetta; Maschio, Aldo Del: Molecular Organization and Functional Regulation of Cell to Cell Junctions in the Endothelium

Symposium

Von Willebrand Disease and Factor

156
Girma, Jean-Pierre; Ribba, Anne-Sophie; Meyer, Dominique: Structure-Function Relationship of the A1 Domain of von Willebrand Factor
161
Sadler, J Evan; Matsushita, Tadashi; Dong, Zhengyu; Tuley, Elodee A; Westfield, Lisa A: Molecular Mechanism and Classification of von Willebrand Disease

Molecular Basis of Fibrinolysis

167
Collen, D; Lijnen, H R: Molecular Basis of Fibrinolysis, as Relevant for Thrombolytic Therapy
172
Bachmann, F: The Enigma PAI-2. Gene Expression, Evolutionary and Functional Aspects

Tissue Factor

180
Nemerson, Yale: Tissue Factor: Then and Now
185
Morrissey, James H: Tissue Factor Modulation of Factor Vlla Activity:Use in Measuring Trace Levels of Factor Vlla in Plasma

Venous Thromboembolism:Diagnosis and Therapy

189
Hull, Russell D; Feldstein, William; Pineo, Graham F; Raskob, Gary E: Cost Effectiveness of Diagnosis of Deep Vein Thrombosis in Symptomatic Patients
197
ten Cate, Jan W; Koopman, Maria M W; Prins, Martin H; Büller, Harry R: Treatment of Venous Thromboembolism

Megakaryocytes

204
Gewirtz, Alan M: Megakaryocytopoiesis: The State of the Art
210
Uzan, Georges; Prandini, Marie Hélè; Berthier, Rolande: Regulation of Gene Transcription During the Differentiation of Megakaryocytes

Colloquium

Platelets,Leukocytes and Endothelial Cells During Inflammation and Thrombosis

213
Marcus, Aaron J; Safier, Lenore B; Broekman, M Johan; Islam, Naziba; Fliessbach, Joan H; Hajjar, Katherine A; Kaminski, Wolfgang E; Jendraschak, Ellen; Silverstein, Roy L; von Schacky, Clemens: Thrombosis and Inflammation as Multicellular Processes: Significance of Cell-Cell Interactions
218
Cerletti, Chiara; Evangelista, Virgilio; Molino, Marina; de Gaetano, Giovanni: Platelet Activation by Polymorphonuclear Leukocytes: Role of Cathepsin G and P-Selectin
224
Furie, Bruce; Furie, Barbara C: The Molecular Basis of Platelet and Endothelial Cell Interaction with Neutrophils and Monocytes: Role of P-Selectin and the P-Selectin Ligand, PSGL-1

Disorders Causing Thrombocytopenia

228
Kelton, John G: The Serological Investigation of Patients with Autoimmune Thrombocytopenia
234
Newman, Peter J; Valentin, Nathalie: Human Platelet Alloantigens: Recent Findings, New Perspectives
240
Moake, Joel L: Thrombotic Thrombocytopenic Purpura
246
Machin, S J; Kelsey, H; Seghatchian, M J; Warwick, R; Mackie, I J: Platelet Transfusion

Symposium

Adhesive Proteins,Integrins,Selectins

253
Ugarova, Tatiana; Agbanyo, Francisca R; Plow, Edward F: Conformational Changes in Adhesive Proteins Modulate Their Adhesive Function
258
Hess, Sibylle; Kanse, Sandip M; Kost, Christine; Preissner, Klaus T: The Versatility of Adhesion Receptor Ligands in Haemostasis: Morpho-Regulatory Functions of Vitronectin

Gene Therapy of Haemophilia A and B

266
Fallaux, Frits J; Hoeben, Rob C; Briët, Ernest: State and Prospects of Gene Therapy for the Hemophilias
274
Furie, Barbara C; Furie, Bruce: Biosynthesis of Factor IX: Implications for Gene Therapy

Thrombosis Cancer

278
Donati, Maria Benedetta: Cancer and Thrombosis: from Phlegmasia Alba Dolens to Transgenic Mice
282
Nierodzik, Mary Lynn; Klepfish, Abraham; Karpatkin, Simon: Role of Platelets, Thrombin, Integrin llb-llla, Fibronectin and Von Willebrand Factor on Tumor Adhesion in Vitro and Metastasis in Vivo

Regulation of Fibrinolysis by Cells and ECM

291
Loscalzo, Joseph; Pasche, Boris; Quimet, Helene; Freedman, Jane E: Platelets and Plasminogen Activation
294
Hajjar, Katherine A: Cellular Receptors in the Regulation of Plasmin Generation

Molecular Basis of Haemophilias

313
Tuddenham, Edward G D; Pemberton, Susan; Cooper, David N: Inherited Factor VII Deficiency: Genetics and Molecular Pathology
322
Antonarakis, Stylianos E: Molecular Genetics of Coagulation Factor VIII Gene and Hemophilia A

Antiphospholipid Antibodies

329
Triplett, Douglas A: Protean Clinical Presentation of Antiphospholipid-Protein Antibodies (APA)
338
Exner, Thomas: Diagnostic Methodologies for Circulating Anticoagulants

Platler Glycoproteins and Genetic Disorders

345
Nurden, Alan T: Polymorphisms of Human Platelet Membrane Glycoproteins: Structure and Clinical Significance
352
Ginsberg, Mark H; Du, Xiaoping; O'Toole, Timothy E; Loftus, Joseph C: Platelet lntegrins

Low Molecular Weight Heparin

360
Hirsh, Jack; Siragusa, Sergio; Cosmi, Benilda; Ginsberg, Jeffrey S: Low Molecular Weight Heparins (LMWH) in the Treatment of Patients with Acute Venous Thromboembolism
364
Kakkar, V V: Effectiveness and Safety of Low Molecular Weight Heparins (LMWH) in the Prevention of Venous Thromboembolism (VTE)

Platelet Vessel Wall Interaction as a Target of Antithrombotic Therapy

369
Hawiger, Jacek: Mechanisms Involved in Platelet Vessel Wall Interaction

Platelet Vessel Wall Interaction as a Target of Antithrombotic Terapy

373
Leung, Lawrence L.K: Application of Combinatorial Libraries and Protein Engineering to the Discovery of Novel Anti-Thrombotic Drugs
377
Vermylen, J: Clinical Trials of Primary and Secondary Prevention of Thrombosis and Restenosis

Thrombi as a Target of Therapy

382
Harpel, Peter C; Hermann, Anita; Zhang, Xiaoxia; Ostfeld, Iris; Borth, Wolfgang: Lipoprotein(a), Plasmin Modulation, and Atherogenesis
387
Lijnen, H R; Collen, D: Fibrinolytic Agents: Mechanisms of Activity and Pharmacology

Leukocytes, Thrombosis and Haemostasis

391
Rickels, Federick R; Hair, Gregory A; Zelf, Richard A; Lee, Elsbeth; Bona, Robert D: Tissue Factor Expression in Human Leukocytes and Tumor Cells

Antiplatelet Drugs

396
Patrono, Carlo; Patrignani, Paola; Rocca, Bianca; Landolfi, Raffele: Characterization of Biochemical and Functional Effects of Antiplatelet Drugs as a Key to Their Clinical Development
401
Goodnight, Scott H: Antiplatelet Therapy with Aspirin: From Clinical Trials to Practice

Vaascular Growth Factor

406
Flugelman, Moshe Y: Inhibition of Intravascular Thrombosis and Vascular Smooth Muscle Cell Proliferation by Gene Therapy
411
Maciag, T; Friesel, R E: Molecular Mechanisms of Fibroblast Growth Factor-1 Traffick, Signaling and Release

Perinatal Haemostasis

415
Andrew, Maureen: Developmental Hemostasis: Relevance to Thromboembolic Complications in Pediatric Patients
426
Bussel, James B: Fetal Neonatal Thrombocytopenia

Plenary Lecture

429
Carmeliet, Peter; Collen, Désiré: Gene Targeting and Gene Transfer Studies of the Biological Role of the Plasminogen/Plasmin System
565
Turpie, Alexander G G; Weitz, Jeffrey I; Hirsh, Jack: Advances in Antithrombotic Therapy: Novel Agents

Management of Haemophilias

437
Mannucci, Pier Mannuccio: Effects of Factor VIII Concentrates on the Immune System of Patients with Hemophilia
440
Aledort, Louis M: Some Aspects on the Management of Hemophilia

Activated Protein C Resistance

444
Griffin, John H; Heeb, Mary J; Kojima, Yumi; Fernández, José A; Kojima, Kazuhisa; Hackeng, Tilman M; Greengard, Judith S: Activated Protein C Resistance: Molecular Mechanisms
449
Bertina, Rogier M; Reitsma, Pieter H; Rosendaal, Frits R; Vandenbroucke, Jan P: Resistance to Activated Protein C and Factor V Leiden as Risk Factors for Venous Thrombosis

Platelet Vessel Wall and Fibrinogen Interactions

454
Sixma, Jan J; Van Zanten, G Henrita; Saelman, Edwin U M; Verkleji, Marilyn; Lankhof, Hanneke; Nieuwenhuis, H Karel; Groot, Philip G de: Platelet Adhesion to Collagen
460
Ruggeri, Zaverio M: The Role of von Willebrand Factor and Fibrinogen in the Initiation of Platelet Adhesion to Thrombogenic Surfaces

New Antithrombins

464
Harker, Laurence A; Hanson, Stephen R; Kelly, Andrew B: Antithrombotic Benefits and Hemorrhagic Risks of Direct Thrombin Antagonists
473
Callas, Demetra; Fareed, Jawad: Comparative Pharmacology of Site Directed Antithrombin Agents. Implication in Drug Development

Clinical Users of Fibric Sealant

482
Spotnitz, William D: Fibrin Sealant in the United States: Clinical Use at the University of Virginia

Clinical Uses of Fibrin Sealant

486
Martinowitz, Uri; Schulman, Sam: Fibrin Sealant in Surgery of Patients with a Hemorrhagic Diathesis

Thrombin as a Target of Antithrombotic Therapy

493
Fenton II, John W: Thrombin Functions and Antithrombotic Intervention
499
Brass, Lawrence F: Issues in the Development of Thrombin Receptor Antagonists

Clinical Coagulation Laboratory and Oral Anticoagulant Therapy Treatment

506
Altman, Raul; Rouvier, Jorge; Gurfinkel, Enrique: Oral Anticoagulant Treatment with and without Aspirin
511
Barbui, Tizsano; Finazzi, Guido; Remuzzi, Andrea: Clinical Coagulation Laboratory and Oral Anticoagulant Therapy Treatment. Instrumentation and Methodology

Clinical Coagulation Laboratory and Oral Anticoagulation Therapy Treatment

515
Preston, F E: Quality Control and Oral Anticoagulation

Thrombopoietin

521
Kaushansky, Kenneth: Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production
526
Vainchenker, William; Methia, Nassia; Debili, Najet; Titeux, Monique; Wendling, Françoise: c-mpl, the Thrombopoietin Receptor

Extracellular Matrix

529
Mosher, Deane F: Organization of the Provisional Fibronectin Matrix: Control by Products of Blood Coagulation
534
Vlodavsky, Israel; Miao, Hua-Quan; Atzmon, Ruth; Levi, Ehud; Zimmermann, Joseph; Bar-Shavit, Rachel; Peretz, Tamar; Ben-Sasson, Shmuel A: Control of Cell Proliferation by Heparan Sulfate and Heparin-Binding Growth Factors

Restenosis

541
Schwartz, Stephen M; Reidy, Michael A; O’Brien, Edward R M: Assessment of Factors Important in Atherosclerotic Occlusion and Restenosis
552
Fuster, Valentin; Falk, Erling; Fallon, John T; Badimon, Lina; Chesebro, James H; Badimon, Juan Jose: The Three Processes Leading to Post PTCA Restenosis: Dependence on the Lesion Substrate

Liproproteins and Thrombosis

560
Aviram, Michael: LDL-Platelet Interaction Under Oxidative Stress Induces Macrophage Foam Cell Formation