Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1995; 74(01): 077-080DOI: 10.1055/s-0038-1642656 Symposium Platelets,Prostaglandins,Lipids,NO Schattauer GmbH Stuttgart Thrombin Generation in Myocardial Infarction and Hypercholesterolemia: Effects of Aspirin Andrzej Szczeklik Department of Medicine, University School of Medicine, Cracow, Poland › Author Affiliations Recommend Article Abstract PDF Download Buy Article PDF (231 kb) References References 1 Swords NA, Mann KG. The assembly of the prothrombinase complex cm adherent platelets. Arterioscl Thromb 1993; 13: 1602-1612 2 Szczeklik A, Musial J, Dropinski J, Krzanowski M, Krolikowski W, Undas A, Swadzba J, Duplaga M, Bodzon W. Thrombinogenesis and its pharmacological modulation in atherosclerosis. J Physiol Pharmacol 1994; 45: 3-11 3 Rugman FP, Jenkins JA, Duguid JK, Maggs PB, Hay CR M. Prothrombin fragment Fl+ 2: correlations with cardiovascular risk factors. Blood Coagul Fibrin 1994; 5: 335-340 4 Giansante C, Fiotti N, Cattin L, Da Col PG, Calabrese S. Fibrinogen, D- dimerand thrombin-antithrombin complexes in a random population sample: Relationships with other cardiovascular risk factors. Thromb Haemost 1994; 71: 581-586 5 Pitney WR, Dacie JV. A simple method for studying the generation of thrombin in recalcified plasma. J Clin Pathol 1953; 6: 9-15 6 Szczeklik A. Generation of the proteolytic activity bound with alpha2macroglobulin during plasma clotting. Clin Chim Acta 1970; 27: 339-348 7 Hemker HC, Wielders S, Kessels H, Beguin S. Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. Thromb Haemost 1993; 70: 617-624 8 Bendetowicz AV, Hu Kai, Knebel R, Caplain H, Hemker C, Lindhout T, Beguin S. The effect of subcutaneous injection of unfractionated and low molecular weight heparin on thrombin generation in platelet rich plasma - a study in human volunteers. Thromb Haemost 1994; 72: 705-712 9 Brommer EJ P, Meijer P. Thrombin generation induced by the intrinsic or extrinsic coagulation pathway is accelerated by streptokinase, independently of plasminogen. Thromb Haemost 1993; 70: 995-997 10 Galhstl S, Muntean W. Thrombin-hirudin complex formation, thrombin- antithrombin III complex formation, and thrombin generation after intrinsic activation of plasma. Thromb Haemost 1994; 72: 387-392 11 Ratnatunga CP, Edmondson SF, Rees GM, Kovacs IB. High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation. Circulation 1992; 85: 1077-1082 12 Thomgren M, Shafi S, Bom GV R. Thromboxane A2 in skin-bleeding time blood and in clotted venous blood before and after administration of acetyl- salicylic acid. Lancet 1983; 1: 1075-1078 13 Kyrle PA, Westwick J, Scully MF, Kakkar VV, Levis GP. Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation ex vivo in man - effect oflow-dose aspirin. Thromb Haemost 1987; 57: 62-69 14 Weiss HI, Lages B. Evidence for tissue factor-dependent activation of the classic extrinsic coagulation mechanism in blood obtained from bleeding time wounds. Blood 1988; 71: 629-635 15 Szczeklik A, Krzanowski M, Gora P, Radwan J. Antiplatelet drags and generation of thrombin in clotting blood. Blood 1992; 80: 2006-2011 16 Szczeklik A, Dropinski J, Gora P. Serum immunoglobulin E and sudden cardiac arrest during myocardial infarction. Coronary Artery Dis 1993; 4: 1029-1032 17 Eisenberg PR, Sherman LA, Jaffe AS. Paradoxic elevation of fibrinopeptide A after streptokinase: Evidence for continued thrombosis despite intense fibrinolysis. J Am Coll Cardiol 1987; 10: 527-529 18 Owen J, Friedman KD, Grossman BA, Wilkins C, Berke AD, Powers ER. Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity. Blood 1988; 72: 616-620 19 Rapold HJ, de Bono D, Arnold AE R, Amout J, de Cock F, Collen D, Verstraete M. Plasma fibrinopeptide A levels in patients with acute myocardial infarction treated with alteplase. Correlation with concomitant heparin, coronary artery patency, and recurrent ischemia. Circulation 1992; 85: 928-934 20 Garabedian HD, Gold HK, Newell IB, Collen D, Hagstrom JN, Bovill EG. Accelerated thrombin generation during anticoagulation in patients with unstable angina pectoris. Blood 1994; 83: 1155-1158 21 ISIS-2 Colleborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected myocardial infarction. Lancet 1988; 2: 349-360 22 The RAPT Investigators. Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2 / Prostaglandin endoperoxids receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. Circulation 1994; 89: 588-595 23 Szczeklik A, Dropinski J, Radwan J, Krzanowski M. Presistent generation of thrombin after acute myocardial infarction. Arterioscl Thromb 1992; 12: 548-553 24 Merlini PA, Bauer KA, Oltrona L, Ardissino D, Cattaneo M, Belli C, Mannucci PM, Rosenberg RD. Presistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation 1994; 90: 61-68 25 Szczeklik A, Milner PC, Birch J, Watkins J, Martin JF. Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thromb Haemost 1986; 56: 283-287 26 Szczeklik A, Schmitz-Schumann M, Krzanowski M, Virchow C. Delayed generation of thrombin in clotting blood of atopic patients with hay fever and asthma. Clin Exp Allergy 1991; 21: 411-415 27 Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990 323: 27-36 28 Patrono C. Aspirin as an antiplatelet drug. N Engl J Med 1994; 330: 1287-1294 29 Watala C, Gwozdzinski K. Effect of aspirin on conformation and dynamics of membrane proteins in platelets and erythrocytes. Biochem Pharmacol 1993; 45: 1343-1349 30 Szczeklik A, Musial J, Undas A, Swadzba J, Gora P, Duplaga M. Aspirin inhibits thrombinogenesis in normocholesterolemic but not in hypercholesterolemic man. Thromb Haemost 1993; 69: 798 31 Grotemeyer KH. Schorafinski HW. Husstedt IW. 2-year follow-up of aspirin responder and aspirin non-responder - a pilot study including 180 post-stroke patients. Thromb Res 1993; 71: 397-403 32 De Lorgeril M, Dureau G, Boissonat P, Ovize M, Monnez C, Monjaud I, Salen P, Renaud S. Increased platelet aggregation afterheart transplantation: influence of aspirin. J Heart Lung Tmasplant 1991; 10: 600-603 33 Davi G, Avema M, Catalano I, Baibagallo C, Ganci A, Notarbartalo A, Ciabattoni G, Patrono C. Increased thromboxane biosynthesis in type Ha hypercholesterolemia. Circulation 1992; 85: 1792-1798 34 Basili S, Maurelli M, Bracaglia D, Massafra S, Pergolini M, Cancrini C, Cara D, Vieri M, Alessandri C, Cordova C. Hypercoagulability state in patients with polygenic hypercholesterolemia. Eur Heart J 1994; 15 (suppl.) 311