Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1995; 74(01): 228-233DOI: 10.1055/s-0038-1642682 Colloquium Disorders Causing Thrombocytopenia Schattauer GmbH Stuttgart The Serological Investigation of Patients with Autoimmune Thrombocytopenia John G Kelton Departments of Medicine and Pathology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada › Author Affiliations Recommend Article Abstract PDF Download Buy Article PDF (335 kb) References References 1 Kelton JG, Gibbons S. Autoimmune platelet destruction: idiopathic thrombocytopenic purpura. Semin Thromb Hemost 1982; 8: 83-104 2 Waters AH. Autoimmune thrombocytopenia: clinical aspects. Semin Hematol 29 (02) 18-25 1992; 3 Karpatkin S Autoimmune thrombocytopenic purpura. Semin Hematol 1985; 22: 260-288 4 Sinha RK, Kelton JG. Current controversies concerning the measurement of platelet-associated IgG. Transfus Med Rev 1990; 4: 121-135 5 Kiefel V, Santoso S, Mueller-Eckhardt C. Serological, biochemical, and molecular aspects of platelet autoantigens. Semin Hematol 1992; 29: 26-33 6 George JN. Platelet IgG: measurement, interpretation, and clinical significance. Prog Hemost Thromb 1991; 10: 97-126 7 Kelton JG, Murphy WG, Lucarelli A, Garvey-Williams J, Santos A, Meyer R, Powers P. A prospective comparison of four techniques for measuring platelet-associated IgG. Br J Haematol 1989; 71: 97-105 8 Harrington WJ, Minnich V, Hollingsworth JW. et al Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 1951; 38: 1-10 9 Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin- induced thrombocytopenia. Blood 1986; 67: 27-30 10 Warkentin TE, Hayward CP M, Smith CA, Kelly PM, Kelton JG. Determinants of donor platelet variability when testing for heparin- induced thrombocytopenia. J Lab Clin Med 1992; 120: 371-379 11 McMillan R, Smith RS, Longmire RL. et a l Immunoglobulins associated with human platelets. Blood 1971; 37: 316-322 12 McMillan R, Luiken GA, Gordon P. et a l Platelet-associated IgG (PAIgG) - An assay of antiplatelet antibody (APA) in immune thrombocytopenic purpura (ITP). Blood 1975; 46: 1034 13 Luiken GA, McMillan R, Lightsey AL. et a l Platelet-associated IgG in immune thrombocytopenic purpura (ITP). Blood 1977; 50: 317-325 14 Dixon R, Rosse W, Ebbert L. Quantitative determination of antibody in idiopathic thrombocytopenic purpura. N Engl J Med 1975; 292: 230-236 15 Kelton JG, Neame PB, Bishop J. et. al. The direct assay for platelet-associated IgG (PAIgG): Lack of association between antibody level and platelet size. Blood 1979; 53: 73-80 16 Kelton JG, Giles AR, Neame PB. et a l Comparison of two direct assays for platelet-associated IgG (PAIgG) in assessment of immune and nonimmune thrombocytopenia. Blood 1980; 55: 424-429 17 LoBuglio AF, Court WS, Vinocur L. et a l Immune thrombocytopenic purpura: Use of a 125I-labelled antihuman IgG monoclonal antibody to quantify platelet-bound IgG. N Engl J Med 1983; 309: 459-463 18 Court WS, LoBuglio AF. Measurement of platelet surface-bound IgG by a monoclonal 125I-anti-IgG assay. Vox Sang 1986; 50: 154-159 19 Schwartz KA. Platelet Antibody: Review of detection methods. Am J Hematol 1988; 29: 106-114 20 Kelton JG, Denomme G, Gauldie J. The majority of platelet- associated IgG (PAIgG) is in the interior of platelets and not measurable using standard assays. Transfusion 1980; 20: 625-626 21 Kelton JG, Denomme G, Lucarelli A, Garvey J, Powers P, Carter C. Comparison of the measurement of surface or total platelet- associated IgG in the diagnosis of immune thrombocytopenia. Am J Hematol 1985; 18: 1-5 22 George JN, Saucerman S, Levine SP. et a l Immunoglobulin G is a platelet alpha granule-secreted protein. J Clin Invest 1985; 76: 2020-2025 23 Hymes K, Shulman S, Karpatkin S. A solid-phase radioimmunoassay for bound anti-platelet antibody. J Lab Clin Med 1979; 94: 639-648 24 Morse BS, Giuliani D, Nussbaum M. Quantitation of platelet- associated IgG by radial immunodiffusion. Blood 1981; 57: 809-811 25 Mueller-Eckhardt C, Kayser W, Mersch-Baumert K, Mueller- Eckhardt G, Breidenbach M, Kugel HJ, Graubner M. The clinical significance of platelet-associated IgG: A study on 298 patients with various disorders. Br I Haematol 1980; 46: 123-131 26 Kelton JG, Powers P, Carter CJ. A prospective study of the usefulness of the measurement of platelet-associated IgG for the diagnosis of idiopathic thrombocytopenic purpura. Blood 1982; 60: 1050-1053 27 Kelton JG. The measurement of platelet-bound immunoglobulins: An overview of the methods and the biological relevance of platelet- associated IgG. Prog Hematol 1983; 8: 163-199 28 Kelton JG, Steeves K. The amount of platelet-bound albumin parallels the amount of IgG on washed platelets from patients with immune thrombocytopenia. Blood 1983; 62: 924-927 29 van Leeuwen EF, van der Ven JT H, Engelfriet CP. et al Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 1982; 59: 23-26 30 Beardsley DS, Spiegel JE, Jacobs MM, Handin RI, Lux SE. Platelet membrane glycoprotein Ilia contains target antigens that bind antiplatelet antibodies in immune thrombocytopenia. J Clin Invest 1984; 74: 1701-1707 31 Mueller-Eckhardt C, Kiefel V, Santoso S. Recent trends in platelet antigen/antibody detection. Blut 1989; 59: 35-43 32 Smith JW, Kelton JG, Horsewood P, Brown C, Giles A, Hunter D, Meyer R, Woods V, Burrows R. Platelet-specific alloantigens (Zava/Zavb) on the platelet glycoprotein Ia/IIa complex. Br J Haematol 1989; 72: 534-538 33 Kelton JG, Smith JW, Horsewood P, Humbert JR, Hayward CP M, Warkentin TE. Gov a/b alloantigen system on human platelets. Blood 1990; 75: 2127-2176 34 Warkentin TE, Smith JW, Hayward CP M, Ali AM, Kelton JG. Thrombocytopenia caused by passive transfusion of anti-glycoprotein Ia/IIa antibody (anti-HPA-5b). Blood 1992; 79: 2480-2484 35 Smith JW, Hayward CP M, Warkentin TE, Horsewood P, Kelton JG. Investigation of human platelet alloantigens and glycoproteins using non-radioactive immunoprecipitation. J Immunol Methods 1993; 158: 77-85 36 Woods Jr VL, Oh EH, Mason D, McMillan R. Autoantibodies against the platelet glycoprotein Ilb/IIIa complex in patients with chronic ITP. Blood 1984; 63: 368-376 37 Fujisawa K, O’Toole TE, Tani P, Loftus JC, Plow EF, Ginsberg MH, McMillan R. Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein Ilia in patients with chronic immune thrombocytopenic purpura. Blood 1991; 77: 2207 38 Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt C. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): A new tool for the identification of platelet-reactive antibodies. Blood 1987; 70: 1732 39 Kiefel V, Santoso S, Kaufmann E, Mueller-Eckhardt C. Autoantibodies against platelet glycoprotein Ib/IX: A frequent finding in autoimmune thrombocytopenic purpura. Br J Haematol 1991; 79: 256
