Platelets and Plasminogen Activation

Joseph Loscalzo; Boris Pasche; Helene Quimet; Jane E Freedman

doi:10.1055/s-0038-1642692

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(01): 291-293
DOI: 10.1055/s-0038-1642692

Symposium

Regulation of Fibrinolysis by Cells and ECM

Schattauer GmbH Stuttgart

Platelets and Plasminogen Activation

Joseph Loscalzo

Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA

,

Boris Pasche

Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA

,

Helene Quimet

Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA

,

Jane E Freedman

Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA

› Author Affiliations

Abstract

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References

References
1 Loscalzo J. Platelets and thrombolysis. J Vase Med Biol 1989; 1: 213-219
2 Coller BS. Platelets and thrombolytic therapy. N Engl J Med 1990; 322: 33-42
3 Adelman B, Rizk A, Banners E. Plasminogen interactions with platelets in plasma. Blood 1989; 72: 1530-1535
4 Miles LA, Dahlberg CM, Plow EF. The cell-binding domains of plasminogen and their function in plasma. J Biol Chem 1988; 263: 11923-811934
5 Miles LA, Plow EF. Binding and activation of plasminogen on the platelet surface. J Biol Chem 1985; 260: 4303-4311
6 Miles LA, Ginsberg MH, White JG, Plow EF. Plasminogen interacts with human platelets through two distinct mechanisms. J Biol Chem 1986; 77: 2001-2009
7 Vaughan DE, Mendelsohn ME, DeClerck PJ, Van Houtte E, Collen D, Loscalzo J. Characterization of the binding of human tissue-type plasminogen activator to platelets. J Biol Chem 1989; 264: 15869-15874
8 Aoki N, Moroi M, Tachiya K. Effects of a2-plasmin inhibitor on fibrin clot lysis. Its comparison with a2-macroglobulin. Thromb Haemost 1978; 39: 22-31
9 Hall SW, Humphries JE, Gonias SL. Inhibition of cell surface receptor- bound plasmin by a2-antiplasmin and a2-macroglobulin. J Biol Chem 1991; 266: 12329-12326
10 Schafer Al, Adelman B. Plasminogen inhibition of platelet function and of arachidonic acid metabolism. J Clin Invest 1985; 75: 456-461
11 Schafer AI, Maas AK, Ware A, Johnson PC, Rittenhouse SE. Platelet protein phosphorylation, evaluation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin. J Clin Invest 1987; 78: 73-79
12 Deutsch DG, Mertz ET. Plasminogen: purification from human plasma by affinity chromatography. Science 1970; 170: 1095-1096
13 Lowry OH, Rosebrough NJ, Farr AL, Randall R. Protein measurement with the folin reagent. J Biol Chem 1951; 193: 265-275
14 Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1987; 72: 248-254
15 Laemmli UK. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 1970; 227: 680-682
16 Timmons S, Hawiger JJ. Separation of human platelets from plasma proteins including factor VIII-vWF by a combined albumin gradient-gel filtration method using Hepes buffer. Thromb Res 1978; 12: 297-306
17 Mendelsohn ME, O’Neill S, George D, Loscalzo J. Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine. J Biol Chem 1990; 265: 19028-19034
18 Loscalzo J, Inbal A, Handin RI. Von Willebrand protein facilitates platelet incorporation in polymerizing fibrin. J Clin Invest 1986; 88: 1112-1119
19 Pasche B, Ouimet H, Francis S, Loscalzo J. Structural changes in platelet glycoprotein Ilb/IIIa by plasmin: determinants andfunctional consequences. Blood 1994; 83: 404-414
20 Matsudaira P. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. I Biol Chem 1987; 262: 10035-10039
21 Ouimet H, Freedman JE, Loscalzo J. Kinetics and mechanism of platelet- surface plasminogen activation by tissue-type plasminogen activator. Biochemistry 1994; 33: 2970-2976