Molecular Organization and Functional Regulation of Cell to Cell Junctions in the Endothelium

Elisbetta Dejana; Aldo Del Maschio

doi:10.1055/s-0038-1642695

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(01): 309-312
DOI: 10.1055/s-0038-1642695

Plenary Lecture

Schattauer GmbH Stuttgart

Molecular Organization and Functional Regulation of Cell to Cell Junctions in the Endothelium

Elisbetta Dejana

Laboratoire de Hematologie, INSERM U217, Département de Biologie Molécuiaire et Structuraie CEN-G, Grenoble, France

,

Aldo Del Maschio

Istituto di Ricerche Farmacologiche Mario Negri, Vascular Biology Laboratory, Milano, Italy

› Author Affiliations

Abstract

PDF Download

PDF (346 kb)

References

References
1 Franke WW, Cowin P, Grand C, Kuhn C, Kepprell HP. The endothelial junction: the plaque and its components. In Endothelial Cell Biology in Health and Disease. Simionescu N, and Simionescu M. eds. New York: Plenum Press; 1988: 147-166
2 Caveda L, Corada M, Martin-Padura I, Del Maschio A, Breviario F, Lampugnani MG, Dejana E. Structural characteristics and functional role of endothelial cell to cell junctions. Endothelium 1994; 2: 1-10
3 Rubin LL. Endothelial cells: adhesion and tight junctions. Curr Opin Cell Biol 1992; 4: 830-833
4 Simionescu N, Simionescu N. Endothelial transport macromolecules: transcytosis and endocytosis. Cell Biology Reviews 1991; 25: 5-80
5 Gumbiner BM. Breaking through the tight junction barrier. J Cell Biol 1993; 123: 1631-1633
6 Anderson JM, Baida MS, Fanning AS. The structure and regulation of tight junctions. Curr Opin Cell Biol 1993; 5: 772-778
7 Risau W, Wolburg H. Development of the blood-brain barrier. Trends Neurosci 1990; 13: 174-178
8 Beyer EC. Gap junctions. Int Rev Cytol 1993; 137 C l-37
9 Furase M, Hi rase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, and Tsukita S. Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123: 1777-1788
10 Hangxin L, Poznansky MJ. Characterization of the ZO-1 protein in endothelial and other cell lines. J Cell Sci 1990; 97: 231-237
11 Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, Louvard D. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction maricer ZO-1 in polarized epithelial cells. J Cell Biol 1994; 124: 101-105
12 Polacek D, Lai R, Volin MV, Davies PF. Gap junctional communication between vascular cells. Induction of connexin-43 messenger RNA in macrophage foam cells of atherosclerotic lesions Am J Pathol 1993; 112: 593-606
13 Geiger B, Ayalon O. Cadherins. Ann Rev Cell Biol 1992; 8: 307-332
14 Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulators. Science 1991; 251: 1451-1455
15 Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. TIG 1993; 9: 317-321
16 Tsukita S, Tsukita S, Nagafuchi A, Yonemura S. Molecularlinkage between cadherins and act in filaments in cell-cell adherens junctions. Cur Opin Cell Biol 1992; 4: 834-839
17 Granwald GB. The structural and functional analysis of cadherin calcium- dependent cell adhesion molecules. Cur Opin Cell Biol 1993; 5: 797-805
18 Ranscht B. Cadherins and catenins: interactions and functions in embryonic development. Cur Opin Cell Biol 1994; 6: 740-756
19 Salomon D, Ayalon O, Patel-King R, Hynes RO, Geiger B. Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci 1992; 102: 1-11
20 Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco LP, Dejana E. A novel endothelial specific membrane protein is a marker of cell-cell contacts. J Cell Biol 1992; 118: 1511-1522
21 Leach L, Clark P, Lampugnani MG, Arroyo AG, Dejana E, Firth JA. Imunoelectron characterization of the inter-endothelial junctions of human term placenta. J Cell Sci 1993; 104: 1073-1081
22 Ayalon O, Sabanai H, Lampugnani MG, Dejana E, Geiger B. Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. J Cell Biol 1994; 126: 247-258
23 Suzuki S, Sano K, Tanihara H. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regulation 1991; 2: 261-270
24 Lampugnani MG, Corada M, Caveda L, Breviario F, Dejana E. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin β-catenin and a-catenin to vascular endothelial cadherin (VE-cadherin). J.Cell Biol in press.
25 Meyer RA, Laird DW, Revel JP, Johnson RG. Inhibition of gap junction and adherens junction assembly by connexin and A.-CAM antibodies. J Cell Biol 1992; 119: 179-189
26 DeLisser HM, Newman PJ, Albelda SM. Molecular and functional aspects of PECAM-1/CD31. Immunol Today 1994; 15: 490-495
27 Lampugnani MG, Resnati M, Dejana E, Marchisio PC. The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol 1991; 112: 479-490
28 Esposito C, Gerlach H, Brett J, Stem D, Vlassara H. Endothelial receptor- mediated binding of glucose-modified albumin is associated with increase permeability and modulation of cell surface coagulant properties. J Exp Medicine 1989; 170: 1387-1407
29 Hoschuetzky H, Aberle H, Kemler R. Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 1994; 127: 1375-1380
30 Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-2101
31 Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-314
32 Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J 1994; 8: 929-938
33 Huang AJ, Silverstein SC. Mechanisms of neutrophil migration across endothelium. In Endothelial cell disfunction Simionescu N, and Simionescu M. eds. Plenum Press; New York: 1992: 201-231
34 Huang AJ, Manning JE, Bandak TM, Ratau MC, Hanser KR, Silverstein SC. Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 1993; 120: 1371-1378
35 Lauri D, Needham L, Dejana E. Tumor cell adhesion to the endothelium. In: Vascular endothelium interactions with circulating cells. Gordon J. ed Elsevier Science Publishers Amsterdam; 1991: 111-125