Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production

Kenneth Kaushansky

doi:10.1055/s-0038-1642732

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(01): 521-525
DOI: 10.1055/s-0038-1642732

Symposium

Thrombopoietin

Schattauer GmbH Stuttgart

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production

Kenneth Kaushansky

Division of Hematology RM-10, University of Washington Seattle, WA, USA

› Author Affiliations

Abstract

PDF Download

PDF (291 kb)

References

1 Debili N, Masse J-M, Katz A, Guichard J, Breton-Gorius J, Vainchenker W. Effects of the recombinant hematopoietic growth factors interleukin-3, interieukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+. cells Blood 1993; 82: 84-95
2 Segal GM, Stueve T, Adamson J W. Analysis of murine megakaryocyte colony size and ploidy:Effects of interleukin-3. J Cell Physiol 1988; 137: 537-544
3 Briddell RA, Bruno E, Cooper RJ, Brandt JE, Hoffman R. Effect of c-kit ligand on in vitro human megakaryocytopoiesis. Blood 1991; 78: 2854-2859
4 Avraham H, Vannier E, Cowley S, Jiang S, Chi S, Dinarello CA, Zsebo KM, Groopman JE. Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells. Blood 1992; 79: 365-371
5 Kaushansky K, O’Hara RJ, Berkner K, Segal GM, Hagen FS, Adamson JW. Genomic cloning, characterization and multilineage growth -promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc Nad Acad Sci USA 1986; 83: 3101-3105
6 Hirayama F, Shih J- P, Awgulewitsch A, Warr GW, Clark SC, Ogawa M. Clonal proliferation of murine lymphohemopoietic progenitors in culture. Proc Natl Acad Sci USA 1992; 89: 5907-5911
7 Hill RJ, Levin J. Regulators of thrombopoiesis:Their biochemistry and physiology. Blood Cells 1989; 15: 141-166
8 McDonald TP. Thrombopoietin:Its biology, purification, and characterization. Exp Hematol 1988; 16: 201-205
9 Hill RJ, Levin J, Levin FC. Correlation of in vitro and in vivo biological activities during the partial purification of thrombopoietin. Exp Hematol 1992; 20: 354-360
10 Carter CD, Schultz W, McDonald TP. Thrombopoietin from human embryonic kidney cells stimulates an increase in megakaryocyte size of sublthally irradiated mice. Radiation Res 1993; 135: 32-39
11 Ishabashi T, Kimura H, Uchida T, Kariyone S, Friese P, Burstein SA. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Nad Acad Sci USA 1989; 86: 5953-5957
12 Quesenberry PJ, McGrath HE, Williams ME, Robinson BE, Deacon DH, Clark S, Urdal D, McNiece IK. Multifactor stimulation of megakaryocytopoiesis :Effects of interleukin 6. Exp Hematol 1991; 19: 35-41
13 Paul SR, Bennett F, Calvetti J A, Kelleher K, Wood CR, O’Hara Jr RM, Leary AC, Sibley B, Clark SC, Williams DA, Yang Y-C. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Nad Acad Sci USA 1990; 87: 7512-7516
14 Kimura H, Ishibashi T, Uchida T, Mamyama Y, Friese P, Burstein SA. Interleukin 6 is a differentiation factor for human megakaryocytes in vitro. Eur J Immunol 1990; 20: 1927-1931
15 Burstein SA, Mei R- L, Henthom J, Friese P, Turner K. Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro. J Cell Physiol 1992; 153: 305-12
16 Metcalf D, Waring P, Nicola NA. Actions of leukaemia inhibitory factor on megakaryocyte and platelet formation. Ciba Foundation Symposium 1992; 167: 174-87
17 Souyri M, Vigon I, Penciolelli J-F, Heard J-M, Tambourin P, Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia vims immortalizes hematopoietic progenitors. Cell 1990; 63: 1137-47
18 Vigon I, Momon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene:Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 1992; 89: 5640-44
19 Cosman D. The hematopoietin receptor superfamily. Cytokine 1993; 5: 95-106
20 Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 1994; 76: 253-62
21 Murakami M, Namzaki M, Masahiko H, Yawata H, Yasukawa K, Hamaguchi M, Taga T, Kishimoto T. Critical cytoplasmic region of the interleukin 6 signal transducer gpl30 is conserved in the cytokine receptor family. Proc Nad Acad Sci USA 1991; 88: 11349-53
22 Martin P, Papayannopoulou T. HEL cells:A new human erythroleukemia cell line with spontaneous and induced globin expression. Science 1992; 216: 1233-35
23 Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV. Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest 1990; 85: 1072-84
24 Vigon I, Dreyfus F, Melle J, Viguie F, Ribrag V, Cocault L, Souyri M, Gisselbrecht S. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood 1993; 82: 877-83
25 Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P. Murine c-mpl:a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 1993; 12: 2645-53
26 Methia N, Louache F, Vainchenker W, Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993; 82: 1395-1401
27 Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Helpel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AF T, Mathewes S L, Bailey MC, Forstrom JW, Buddie MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O’Hara PJ, Hagen FS, Roth GJ, Foster DC. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994; 369: 565-68
28 de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gumey AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg Jr. LA, Goeddel DV, Eaton DL. Stimulation of megakaiyocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994; 369: 533-38
29 Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu H S, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Homkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994; 77: 1117-24
30 Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Letters 1994; 353: 57-61
31 Kuter DJ, Beeler DL, Rosenberg RD. The purification and physiological characteristics of ovine thrombopoietin. Blood 1994; 84 Suppl (Suppl. 01) 242a (abstr)
32 Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddie MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994; 369: 568-71
33 Kaushansky K, Broudy VC, Lin N, Jorgensen M, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C. Thrombopoietin, the MPL ligand, is essential for full megakaryocyte development. (in press)
34 Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369: 571-74
35 Choi E, Nichol J, Hokom M, Homkohl A, Hunt P. Recombinant human MGDF (rhuMGDF), a ligand for c-Mpl, produces functional platelets from megakaryocytes in vitro. Blood 1994; 84 Suppl (Suppl. 01) 242a (abstr)
36 Broudy VC, Lin N, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin and stem cell factor to enhance murine megakaryocyte colony growth and increases megakaryocyte polyploidy in vitro. Blood 1994; 84 Suppl (Suppl. 01) 33Qa (abstr)
37 Levin J, Levin FC, Metcalf D. The effects of acute thrombocytopenia on megakaryocyte-CFC and granulocyte-macrophage-CFC in mice:Studies of bone marrow and spleen. Blood 1980; 56: 274-83
38 Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science 1994; 265: 1445-47
39 Sprugel KH, Humes JM, Grossman A, Ren HP, Kaushansky K. Recombinant thrombopoietin stimulates rapid platelet recovery in thrombocytopenic mice. Blood 1994; 84 Suppl (Suppl. 01) 242a abstr
40 Hunt P, Hokom M, Dwyer E, Faust J, del Castillo J, Chen J, Knutden A, Li Y-S, Bartley T, Bogenberger J, Homkohl A, Choi E, Nichol J, Toombs C, Sheridan C, Bosselman R, Ulich T. Megakaryocyte growth and development factor (MGDF) is a potent, physiological regulator of platelet production in normal and myelocompromised animals. Blood 1994; 84 Suppl (Suppl. 01) 390a abstr
41 Ballmaeir M, Bogenberger J, Shutter J, Welcher A, Tidow N, Konig A, Wilken Av, Schweinitz D, Hadam M, Welte K. Analysis of expression of megakaryocyte growth and development factor mRNA in various human normal and malignant tissues. Blood. 1994
42 McCarty JM, Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1994; 84 Suppl (Suppl. 01) 241a abstr
43 Heaney ML, Golde DW. Soluble hormone receptors. Blood 1993; 82: 1945-1948