Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1995; 74(01): 156-160DOI: 10.1055/s-0038-1642669 Symposium Von Willebrand Disease and Factor Schattauer GmbH Stuttgart Structure-Function Relationship of the A1 Domain of von Willebrand Factor Jean-Pierre Girma INSERM U. 143, Hôpital de Bicêtre, Paris, France , Anne-Sophie Ribba INSERM U. 143, Hôpital de Bicêtre, Paris, France , Dominique Meyer INSERM U. 143, Hôpital de Bicêtre, Paris, France › Author Affiliations Recommend Article Abstract PDF Download Buy Article PDF (361 kb) References References 1 Meyer D, Giima JP. von Willebrand Factor - structure and function. Hiromb Haemost 1993; 70: 99-104 2 Fujimura Y, Titani K, Holland LZ, Russel SR, Roberts JR, Elder JH, Ruggeri ZM, Zimmerman TS. von Willebrand Factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein lb J Biol Chem 1986; 261: 381-385 3 Cruz MA, Handin RI, Wise RJ. The interaction of the von Willebrand Factor-A 1 domain with platelet Glycoprotein-Ib/TX -the role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein. J Biol Chem 1993; 268: 21238-21245 4 Sugimoto M, Ricca G, Hrinda ME, Schreiber AB, Searfoss GH, Bottini E, Ruggeri ZM. Functional modulation of the isolated glycoprotein-lb binding domain of von W illebrand factor expressed in Escherichia coli. Biochemistry 1991; 30: 5202-5209 5 Gralnick HR, Williams S, McKeown L, Kramer W, Krutzsch H, Gorecki M, Pinet A, Garfinkel LI. A monomeric von Willebrand factor fragment, Leu-504-Ser-728, inhibits von Willebrand factor interaction with glycoprotein-Ib-EX. Proc Natl Acad Sci USA 1992; 89: 7880-7884 6 Azuma H, Dent JA, Sugimoto M, Ruggeri ZM, Ware J. Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein-Ib-binding site. J Biol Chem 1991; 266: 12342-12347 7 Pietu G, Meulien P, Cherel G, Diaz J, Baruch D, Courtney M, Meyer D. Production in Escherichia coli of a biologically active subfragment of von Willebrand Factor corresponding to the platelet glycoprotein lb, collagen and heparin binding domains. Biochem Biophys Res Commun 1989; 164: 1339-1347 8 Andrews RK, Gorman JJ, Booth WJ, Corino GL, Castaldi PA, Bemt MC. Cross-linking of amonomeric 39/34kDadispase fragment of von Willebrand Factor (Leu 480/ Val 481-Gly 718) to the N-terminal region of the a-chain of membrane glycoprotein lb on the intact platelets with bis (sulfosuccinimidyl) suberate. Biochemistry 1989; 28: 8326-8336 9 Denis C, Baruch D, Kielty CM, Ajzenberg N, Christophe O, Meyer D. Localization of von Willebrand factor binding domains to endothelial extracellular matrix and to Type VI collagen. Arterioscler Thromb 1993; 13: 398-406 10 Sakariassen KS, Bolhuis PA, Sixma JJ. Human blood platelet adhesion to artery subendothelium is mediated by factor VIH-von Willebrand factor bound to the subendothelium. Nature 1979; 279: 635-638 11 Mohri H, Yoshioka A, Zimmerman TS, Ruggeri ZM. Isolation of the von Willebrand Factor domain interacting with platelet glycoprotein lb, heparin, and collagen and characterization of its three distinct functional sites. J Biol Chem 1989; 264: 17361-17367 12 Fressinaud E, Baruch D, Girma JP, Sakariassen KS, Baumgartner HR, Meyer D. vest Willebrand factor-mediated platelet adhesion to collagen involves platelet membrane glycoprotein Ilb/IIIa as well as glycoprotein lb. J Lab Clin Med 1988; 112: 58-67 13 Sobel M, Mcneill PM, Carlson PL, Kermode JC, Adelman B, Conroy R, Marques D. Heparin inhibition of von Willebrand factor-dependent platelet function in vitro and in vivo. J Clin Invest 1991; 87: 1787-1793 14 Savage B, Shattil SJ, Ruggeri ZM. Modulation of platelet function through adhesion receptors - A dual role for glycoprotein-IIb-IIIa (integrin-alpha(IIb)beta(3) mediated by fibrinogen and glycoprotein-Ib-von Willebrand factor. J Biol Chem 1992; 267: 11300-11306 15 Bemdt MC, Ward CM, Booth WJ, Castaldi PA, Mazurov AV, Andrews R. Identification of aspartic acid-514 through glutamic acid-542 as a glycoprotein-Ib-IX complex receptor recognition sequence in von Willebrand factor - Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin. Biochemistry 1992; 31: 11144-11151 16 Sugimoto M, Mohri H, McClintock RA, Ruggeri ZM. Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin - A model for the regulation of von Willebrand factor binding to platelet glycoprotein-lb. J Biol Chem 1991; 266: 18172-18178 17 Ginsburg D, Sadler JE. von Willebrand disease - a database of point mutations, insertions, and deletions. Thromb Haemost 1993; 69: 177-184 18 Ribba AS, Christophe O, Derlon A, Cherel G, Siguret V, Girma JP, Meyer D, Pietu G. Discrepancy between IIA phenotype and IIB genotype in a patient with a variant of von Willebrand disease. Blood 1994; 83: 833-841 19 Miura S, Fujimura Y, Sugimoto M, Kawasaki T, Ikeda Y, Titani K, Yoshioka A. Structural elements influencing von Willebrand Factor (vWF) binding affinity for platelet glycoprotein lb within a dispase-digested vWF fragment. Blood 1994; 84: 1553-1558 20 Azuma H, Hayashi T, Dent JA, Ruggeri ZM, Ware J. Disulfide bond requirements for assembly of the platelet glycoprotein-Ib-binding domain of von Willebrand factor. J Biol Chem 1993; 268: 2821-2827 21 Sobel M, Soler DF, Kermode JC, Harris RB. Localization and characterization of a heparin binding domain peptide of human von Willebrand Factor. J Biol Chem 1992; 26718857-26718862 22 Hilbert L, Gaucher C, de Romeuf C, Horellou MH, Vink T, Mazurier C. Leu697Val mutation in mature von Willebrand Factor is responsible for type 2B von Willebrand disease. Blood 1994; 83: 1542-1550
