The Role of von Willebrand Factor and Fibrinogen in the Initiation of Platelet Adhesion to Thrombogenic Surfaces

Zaverio M Ruggeri

doi:10.1055/s-0038-1642722

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(01): 460-463
DOI: 10.1055/s-0038-1642722

Symposium

Platelet Vessel Wall and Fibrinogen Interactions

Schattauer GmbH Stuttgart

The Role of von Willebrand Factor and Fibrinogen in the Initiation of Platelet Adhesion to Thrombogenic Surfaces

Zaverio M Ruggeri

Room Research Laboratory for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemostasis, Departments of Molecular and Experimental Medicine and Vascular Biology The Scripps Research Institute, La Jolla, CA, USA

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Abstract

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References

1 Weiss HJ. Platelet physiology and abnormalities of platelet function. N. Engl. J Med 1975; 293 (531) 580-588
2 Sixma JJ, Waster J. The hemostatic plug. Semin. Hematol 1977; 14: 265-299
3 Falk E. Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death: autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.. Circulation 1985; 71: 699-708
4 Fuster V, Steele PM, Chesebro JH. Role of platelets and thrombosis in coronary atherosclerotic disease and sudden death. J Am Coll Cardiol 1985; 5: 175B-184B.
5 Davies MJ, Thomas AC, Knapman PA, Hangartner JR. Intramyocardial platelet aggregation in patients with unstable angina suffering sudden ischemic cardiac death. Circulation 1986; 73: 418-427
6 Fitzgerald DJ, Roy L, Catella F, Fitzgerald GA. Platelet activation in unstable coronary disease. N. Engl. J. Med 1986; 315: 983-989
7 Nieuwenhuis HK, Akkerman J WN, Houdijk WP M, Sixma JJ. Human blood platelets showing no response to collagen fail to express surface glycoprotein la. Nature 1985; 318: 470-472
8 Ruggeri ZM, De Marco L, Gatti L, Bade rR, Montgomery RR. Platelets have more than one binding site for von Willebrand factor. J. Clin. Invest. 1983; 72: 1-12
9 Plow EF, McEver RP, Coller BS, Woods Jr VL, Marguerie GA, Ginsberg MH. Related binding mechanisms for fibrinogen, fibronectin,von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. Blood 1985; 66: 724-727
10 Coller BS, Peerschke El, Scudder LE, Sullivan CA. Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: Additional evidence in support of GPIb as a platelet receptor for von Willebrand factor. Blood 1983; 61: 99-l10
11 De Marco L, Mazzucato M, Masotti A, Fenton II JW, Ruggeri ZM. Function of glycoprotein Iba in platelet activation induced by a-thrombin. J. Biol. Chem. 1991; 266: 23776-23783
12 Alevriadou BR, Moake JL, Turner NA, Ruggeri ZM, Folie BJ, Phillips MD, Schreiber AB, Hrinda ME, Mclntire LV. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 1993; 81: 1263-1276
13 Baumgartner HR. The role of blood flow in platelet adhesion, fibrin deposition and formation of mural thrombi. Microvasc.Res. 1973; 5: 167-179
14 Sakariassen KS, Bolhuis PA, Sixma JJ. Human blood platelet adhesion to artery subendothelium is mediated by factor VUI/von Willebrand factor bound to the subendothelium. Nature 1979; 279: 636-638
15 Weiss HJ, Turitto VT, Baumgartner HR. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate-dependent decrease of adhesion in von Willebrand’s disease and the Bemard-Soulier syndrome. J. Lab. Clin. Med 1978; 92: 750-764
16 Turitto VT, Weiss HJ, Baumgartner HR. Platelet interaction with rabbit subendothelium in von Willebrand’s disease: altered thrombus formation distinct from defective platelet adhesion. J. Clin. Invest. 1984; 74: 1730-1741
17 Hantgan RR, Hindriks G, Taylor RG, Sixma JJ, de Groot PG, Glycoprotein lb. von Willebrand Factor, and glycoprotein Ilb.IIIa are all involved in platelet adhesion to fibrin in flowing whole blood. Blood 1990; 76: 345-353
18 Titani K, Kumar S, Takio K, Ericsson LH, Wade RD, Ashida K, Walsh KA, Chopek MW, Sadler JE, Fujikawa K. Amino acid sequence of human von Willebrand factor. Biochemistry 1986; 25: 3171-3184
19 Sadler JE, Shelton-Inloes BB, Sorace JM, Harlan JM, Titani K, Davie EW. Cloning and characterization of two cDNAs coding for human von Willebrand factor. Proc. Natl. Acad. Sci. USA 1985; 82: 6394-6398
20 Ginsburg D, Handin RI, Bonthron DT, Donlon TA, Bruns G AP, Latt SA, Orkin SH. Human von Willebrand factor (vWF): Isolation of complementary DNA (cDNA) clones and chromosomal localization. Science 1985; 228: 1401-1406
21 Sadler JE, Shelton-Inloes BB, Sorace JM, Titani K. Cloning of cDNA and genomic DNA for human von Willebrand factor. Cold Spring Harbor Symposia on Quantitative Biology 1986; 51: 515-523
22 Mancuso DJ, Tuley EA, Westfield LA, Worrall NK, Shelton-Inloes BB, Sorace JM, Alevy YG, Sadler JE. Structure of the gene for human von Willebrand factor. J. Biol. Chem. 1989; 264: 19514-19527
23 Mancuso DJ, Tuley EA, Westfield LA, Lester-Mancuso TL, Le Beau MM, Sorace JM, Sadler JE. Human von Willebrand factor gene and pseudogene: Structural analysis and differentiation by polymerase chain reaction. Biochemistry 1991; 30: 253-269
24 Ruggeri ZM, Ware J. von Willebrand factor. FASEB J. 1993; 7: 308-316
25 Fujimura Y, Titani K, Holland LZ, Russell SR, Roberts JR, Elder JH, Ruggeri ZM, Zimmerman TS. von Willebrand factor. A reduced and alkylated 52/48 kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein lb. J. Biol. Chem. 1986; 261: 381-385
26 Shelton-Inloes BB, Titani K, Sadler JE. cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms. Biochemistry 1986; 25: 3164-3171
27 Andrews RK, Gorman JJ, Booth WJ, Corino GL, Castaldi PA, Bemdt MC. Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481 -Gly-718) to the N-terminal region of the a-chain of membrane glycoprotein lb on intact platelets with Lis(sulfosuccinimidyl) suberate. Biochemistry 1989; 28: 8326-8336
28 Cruz MA, Handin RI, Wise RJ. The interaction of the von Willebrand factor-Al domain with platelet glycoprotein Ib/IX. J. Biol. Chem. 1993; 268: 21238-21245
29 Gralnick HR, Williams S, McKeown L, Kramer W, Krutzsch H, Gorecki M, Pinet A, Garfinkel LI. A monomeric von Willebrand factor fragment, Leu-504-Ser-728, inhibits von Willebrand factor interaction with glycoprotein Ib-IX. Proc.Natl.Acad.Sci. 1992; 89: 7880-7884
30 Sugimoto M, Dent J, McClintock RA, Ware J, Ruggeri ZM. Analysis of structure-function relationship in the platelet membrane glycoprotein Ib-binding domain of von Willebrand factor by expression of deletion mutants. J. Biol. Chem. 1993; 268: 12185-12192
31 Howard MA, Firkin BG. Ristocetin A new tool in the investigation of platelet aggregation. Thromb. Haemost. 1971; 26: 362-369
32 Read MS, Shermer RW, Brinkhous KM. Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. Proc. Natl. Acad. Sci. USA. 1978; 75: 4514-4518
33 Scott JP, Montgomery RR, Retzinger GS. Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets. J. Biol. Chem. 1991; 266: 8149-8155
34 Read MS, Smith SV, Lamb MA, Brinkhous KM. Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor. Blood 1989; 74: 1031-1035
35 Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Bemdt MC. Purification of botrocetin from bothrops jararaca venom. Analysis ofbotrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex. Biochemistry 1989; 28: 8317-8326
36 Fujimura Y, Titani K, Usami Y, Suzuki M, Oyama R, Matsui T, Fukui H, Sugimoto M, Ruggeri ZM. Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of bothrops jararaca. Biochemistry 1991; 30: 1957-1964
37 Ruggeri ZM, Pareti FI, Mannucci PM, Ciavarella N, Zimmerman TS. Heightened interaction between platelets and Factor VUI/von Willebrand factor in a new subtype of von Willebrand’s disease. N. Engl. J. Med. 1980; 302: 1047-1051
38 Ruggeri ZM, Zimmerman TS. Variant von Willebrand’s disease: characterization of two subtypes by analysis of multimeric composition of factor VUI/von Willebrand factor in plasma and platelets. J. din. Invest. 1980; 65: 1318-1325
39 Ware J, Dent JA, Azuma H, Sugimoto M, Kyrle PA, Yoshioka A, Ruggeri ZM. Identification of a point mutation in Type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet GP Ib-IX receptor. Proc. Natl. Acad. Sci. USA 1991; 88: 2946-2950
40 Sugimoto M, Mohri H, McClintock RA, Ruggeri ZM. Identification of discontinuous von Willebrand factor sequences involved in complex formation with Botrocetin: a model for the regulation of von Willebrand factor binding to platelet glycoprotein lb. J. Biol. Chem. 1991; 266: 18172-18178
41 Ginsburg D, Sadler JE. von Willebrand Disease: A Database of point mutations, insertions and deletions. Thromb Haemost 1993; 69: 177-184
42 Farrell DH, Thiagarajan P, Chung DW, Davie EW. Role of fibrinogen a and gamma chain sites in platelet aggregation. Proc. Natl. Acad. Sci. USA 1992; 89: 10729-10732
43 Farrell DH, Thiagarajan P. Binding of recombinant fibrinogen mutants to platelets. J. Biol. Chem. 1994; 269: 226-231
44 Savage B, Shattil SJ, Ruggeri ZM. Modulation of platelet function through adhesion receptors: A dual role for glycoprotein Ilb-IIIa (integrin c^Biy mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J. Biol. Chem. 1992; 267: 11300-11306
45 Savage B, Ruggeri ZM. Selective recognition of adhesive sites in surface-bound fibrinogen by GP Ilb-IIIa on nonactivated platelets. J. Biol.Chem. 1991; 266: 11227-11233