Subscribe to RSS
DOI: 10.1055/s-0038-1646010
The Influence of Low Molecular Weight Heparin in Combination with Dihydroergotamine on Experimental Thrombosis and Haemostasis
Publication History
Received 28 October 1986
Accepted after revision 09 June 1987
Publication Date:
28 June 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/198703/lookinside/thumbnails/10-1055-s-0038-1646010-1.jpg)
Summary
The influence of low molecular weight heparin in combination with dihydroergotamine (DHE) on thrombus formation and primary haemostasis was investigated in rabbit models. Conventional heparin in the dose of 60 units anti Xa activity/kg b. w. effectively prevented thrombus formation but the same dose of a low molecular weight fragment only gave a marginal decrease of the frequency of thrombosis. The thrombus weight was, however, significantly reduced. Doubling the dose of the heparin fragment totally abolished thrombus formation as did the combination of 60 units with DHE. With DHE it was also possible to diminish the low molecular weight heparin dose to 30 units with a good prophylactic effect. There was a small but significant increase of haemostatic plug formation time in all treatment groups except the one with low molecular weight heparin fragment 30 units anti Xa activity combined with DHE. Thus, by combining low molecular weight heparin in a low dose with DHE it is possible to prevent thrombus formation without influencing primary haemostasis in rabbits.
-
References
- 1 Bergqvist D. Postoperative thromboembolism. Frequency, etiology, prophylaxis. Springer-Verlag. Berlin; Heidelberg - New York: 1983
- 2 Gruber UF. Prevention of fatal postoperative pulmonary embolism by heparin dihydroergotamine or Dextran 70. Br J Surg 1982; 69: 54
- 3 Carter CJ, Kelton JG, Hirsh J, Cerskus A, Santos AV, Gent M. The relationship between the haemorrhagic and antithrombotic properties of low molecular weight heparin in rabbits. Blood 1982; 59: 1239-1245
- 4 Esquivel CO, Bergqvist D, Bjorck C-G, Nilsson B. Comparison between commercial heparin, low molecular weight heparin and pentosan polysulphate on hemostasis and platelets in vivo. Thromb Res 1982; 28: 389-399
- 5 Bjorck C-G, Bergqvist D, Esquivel C, Nilsson B, Rudsvik Y. Effect of heparin, low molecular weight (LMW) heparin and a heparin analogue on experimentel venous thrombosis in the rabbit. Acta Chir Scand 1984; 150: 629-633
- 6 Peterson J, Zucker MB. The effect of adenosine monophosphate, arcaine and anti-inflammatory agents on thrombosis and platelet function in rabbits. Thromb Diath Haemorrh 1970; 23: 148-158
- 7 Bergqvist D. Haemostatic plug formation in the rabbit mesentery. A methodological study. Ups J Med Sci 1974; 79: 28
- 8 Bergqvist D, Nilsson B, Hedner U, Pedersen PC, Ostergaard PB. The effect of heparin fragments of different molecular weights on experimental thrombosis and haemostasis. Thromb Res 1985; 38: 589-601
- 9 Cade JF, Buchanan MR, Boneu B, Ockelford P, Carter CJ, Cerskus AL, Hirsh J. A comparison of the antithrombotic and haemorrhagic effects of low molecular heparin fractions: The influence of the method of preparation. Thromb Res 1984; 35: 613
- 10 Nilsson B, Bergqvist D, Hedner U, Pedersen PC, Ostergaard PB. Effects of low molecular weight heparins (LMWH) prepared by three different methods on experimental thrombosis and haemostasis in rabbits. Thromb Haemostas 1985; 54: 31 (Abstr)
- 11 Holmer E, Mattsson C, Nilsson S. Anticoagulant and antithrombotic effects of heparin and low molecular weight heparin fragments in rabbits. Thromb Res 1982; 25: 475-485
- 12 Buttermann G, Theisinger W, Oechsler H, Hor G. Untersuchungen über die postoperative Thromboembolicprophylaxe nach einem neuen medikamentosen Behandlungsprinzip. Dtsch Med Wochenschr 1975; 100: 2065
- 13 Fey KH, Herzfeld U, Saggau W, Oehlschlager M. Postoperative Thromboseprophylaxe durch Tonisierung des kaudalen Venen- systems. Med Klin 1975; 70: 1553
- 14 Miihe E, Burghardt K-H, Strobel Cj. Eine neue Methode zur Prophylaxe postoperativer Venenthrombosen. Klinikarzt 1975; 4: 88
- 15 Bergqvist D. Prevention of postoperative thromboembolism in Sweden. The development of pratice during five years. Thromb Haemostas 1985; 53: 239-241
- 16 Schlag G, Grunwald M, Redl H. Expcrimentcller Beitrag zur Throm- boseproblematik. In: Postoperative Thrombocmbolie-Prophvlaxc aus aktucller Sicht. Tscherne FI, Dcutsch E. (eds.) Georg Tliieme Verlag; Stuttgart - New York: 1981
- 17 Bergqvist D, Arvidsson S, Esquivel CO, Lindblad B, Haglund U. The effect of serotonin inhibition on initial microvessel hemostasis and platelet aggregation in vivo. Thromb Haemostas 1983; 49: 173-175
- 18 Schmitz-Huebner U, Biinte H, Freise G. et al Clinical efficacy of low molecular weight heparin in postoperative thrombosis prophylaxis. Klin Wochenschr 1984; 62: 349-353
- 19 Bergqvist D, Burmark US, Frisell J. et al Low molecular weight heparin once daily compared with conventional low-dose heparin twice daily. A prospective double-blind multicentre trial on prevention of postoperative thrombosis. Br J Surg 1986; 73: 204-208
- 20 Rudofsky G. Nachwcis der ganztagigen Wirksamkeit einer s. c. Akutgabe von Dihydroergotamin. Herz-Krcisl. (in press)
- 21 Sasahara AA, Koppenhagen K, Haring R, Welzel D, Wolf H. Low molecular weight heparin plus dihydroergotamine for prophylaxis of postoperative deep vein thrombosis. Br J Surg 1986; 73: 697-700