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Thromb Haemost 1994; 72(01): 070-073
DOI: 10.1055/s-0038-1648813
DOI: 10.1055/s-0038-1648813
Original Article
Protein C Is Responsible for the Rapid Inactivation of Factor Va following Blood Clotting In Vitro
Weitere Informationen
Publikationsverlauf
Received 05. Januar 1994
Accepted after revision 24. März 1994
Publikationsdatum:
12. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199401/lookinside/thumbnails/10-1055-s-0038-1648813-1.jpg)
Summary
When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.
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