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Thromb Haemost 1994; 72(01): 070-073
DOI: 10.1055/s-0038-1648813
Original Article
Schattauer GmbH Stuttgart

Protein C Is Responsible for the Rapid Inactivation of Factor Va following Blood Clotting In Vitro

Denise E Jackson
The Department of Medicine, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
,
Christina A Mitchell
The Department of Medicine, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
,
Hatem H Salem
The Department of Medicine, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
› Author Affiliations
Further Information

Publication History

Received 05 January 1994

Accepted after revision 24 March 1994

Publication Date:
12 July 2018 (online)

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Summary

When whole blood is allowed to clot in vitro, factor V is rapidly activated to factor Va which is subsequently inactivated. We developed two monoclonal anti-protein C antibodies, one of which inhibits protein C activation and the other inhibits protein C activity. The addition of either antibody to blood before clotting in vitro significantly inhibited the inactivation of factor Va, confirming the essential role of protein C in mediating the rapid inactivation of factor Va.

 

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