Generalized Shwartzman Reaction Induced by Liquoid in the Rat

Stein A. Evensen; David Shepro

doi:10.1055/s-0038-1649084

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(02): 347-351
DOI: 10.1055/s-0038-1649084

Original Article

Schattauer GmbH

Generalized Shwartzman Reaction Induced by Liquoid in the Rat

Increased DNA-Synthesis in Aortic Endothelium

Stein A. Evensen^*

¹Biological Science Center, Boston University, Boston, Mass. 02215, USA

,

David Shepro

¹Biological Science Center, Boston University, Boston, Mass. 02215, USA

› Author Affiliations

Abstract

Summary

In an autoradiographic study the number of DNA-synthesizing aortic endothelial cells was compared 48 hours after an intravenous injection of the acidic polymer Liquoid or saline in rats. Doses of 1.5-2 mg per 100 g body weight produced a 14-fold increase in DNA-synthesizing endothelial cells and the generalized Shwartzman reaction. These results show that Liquoid causes severe endothelial injury.

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References

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