A 3.5-Second Phenomenon in Haemostasis

D Thilo; E Böhm

doi:10.1055/s-0038-1649086

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(02): 363-370
DOI: 10.1055/s-0038-1649086

Original Article

Schattauer GmbH

A 3.5-Second Phenomenon in Haemostasis

A Scanning Electron Microscopic Study

D Thilo

¹Blood Coagulation Laboratory (Head: Prof. Dr. F. Duckert) of the Department of Medicine (Director Prof. Dr. F. Koller) University of Basle, Switzerland

²Institute for Forensic Medicine (Director Prof. Dr. Spann), University of Munich, Germany

,

E Böhm

¹Blood Coagulation Laboratory (Head: Prof. Dr. F. Duckert) of the Department of Medicine (Director Prof. Dr. F. Koller) University of Basle, Switzerland

²Institute for Forensic Medicine (Director Prof. Dr. Spann), University of Munich, Germany

› Author Affiliations

Abstract

Summary

Experiments with injury of the abdominal rat skin were carried out to examine the haemostatic system mechanism in vivo after zero to 30 seconds bleeding time. In the bleeding area only a few platelet aggregates could be found with no primary platelet thrombus. After 3.5 second bleeding time the first fibrin strands have been observed at the site of injury. The hypothesis is put forward that there is a very fast reacting haemostatic mechanism which results in the fibrin formation already at 3.5 seconds.

Full Text

References

References
1 Arnold M. 1968. Histochemie. Springer Verlag; 171.
2 Böhm E, and Tschomakov M. 1972 Frühe Merkmale einer vitalen Reaktion - Untersuchungen an Schnittverletzungen der Rattenhaut. Zeitschrift für Rechtsmedizin, in press.
3 Frost H. 1971; Untersuchungen der arteriellen Gefäß Innenfläche mit den Rasterelektronenmikroskop. Thrombosis et Diathesis Haemorrhagica, Suppl 50: 105.
4 Holmsen H, Day H. J, and Stormorken H. 1969; The blood platelet release reaction. Scandinavian Journal of Haematology, Suppl 8: 1.
5 Hovig T. 1970; The role of platelets in thrombosis. Thrombosis et Diathesis Haemorrhagica, Suppl 42: 137.
6 Hugues J, and Lapière C. M. 1964; Nouvelles recheres sur l’accolement des plaquettes aux fibres de collagène. Thrombosis et Diathesis Haemorrhagica 11: 327.
7 Jamieson G. A, Urban C, and Barber A. J. 1971 An enzymatic basis for platelet-collagen-adhesion. Abstract volume II. International Congress on Thrombosis and Haemostasis, Oslo, p. 220.
8 Johnson S. A. 1971. Endothelial supporting function of platelets. In: Johnson S. A. (ed.) Circulating Platelet. Academic Press; New-York, London: 283.
9 Marr J, Barboriak J. J, and Johnson S. A. 1965; Relationship of appearance of adenosine diphosphate, fibrin formation and platelet aggregation in the haemostatic plug in vivo. Nature 205: 259.
10 Vinazzer H. 1972. Gerinnungsstörungen in der Praxis. G. Fischer Verlag; Stuttgart: 2.
11 Zucker M. B. 1947; Platelet agglutination and vasoconstriction as factors in spontaneous haemostasis in normal, thrombocytopenic, heparinized and hypothrombinemic rats. American Journal of Physiology 148: 275.