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Thromb Haemost 1973; 30(02): 363-370
DOI: 10.1055/s-0038-1649086
Original Article
Schattauer GmbH

A 3.5-Second Phenomenon in Haemostasis

A Scanning Electron Microscopic Study
D Thilo
1   Blood Coagulation Laboratory (Head: Prof. Dr. F. Duckert) of the Department of Medicine (Director Prof. Dr. F. Koller) University of Basle, Switzerland
2   Institute for Forensic Medicine (Director Prof. Dr. Spann), University of Munich, Germany
,
E Böhm
1   Blood Coagulation Laboratory (Head: Prof. Dr. F. Duckert) of the Department of Medicine (Director Prof. Dr. F. Koller) University of Basle, Switzerland
2   Institute for Forensic Medicine (Director Prof. Dr. Spann), University of Munich, Germany
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Publikationsverlauf

Received for publication 08. Juni 1973

Accepted for publication 27. Juni 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

Experiments with injury of the abdominal rat skin were carried out to examine the haemostatic system mechanism in vivo after zero to 30 seconds bleeding time. In the bleeding area only a few platelet aggregates could be found with no primary platelet thrombus. After 3.5 second bleeding time the first fibrin strands have been observed at the site of injury. The hypothesis is put forward that there is a very fast reacting haemostatic mechanism which results in the fibrin formation already at 3.5 seconds.

 

  • References

  • 1 Arnold M. 1968. Histochemie. Springer Verlag; 171.
    Suche in Google Scholar
  • 2 Böhm E, and Tschomakov M. 1972 Frühe Merkmale einer vitalen Reaktion - Untersuchungen an Schnittverletzungen der Rattenhaut. Zeitschrift für Rechtsmedizin, in press.
    PubMedSuche in Google Scholar
  • 3 Frost H. 1971; Untersuchungen der arteriellen Gefäß Innenfläche mit den Rasterelektronenmikroskop. Thrombosis et Diathesis Haemorrhagica, Suppl 50: 105.
    PubMedSuche in Google Scholar
  • 4 Holmsen H, Day H. J, and Stormorken H. 1969; The blood platelet release reaction. Scandinavian Journal of Haematology, Suppl 8: 1.
    PubMedSuche in Google Scholar
  • 5 Hovig T. 1970; The role of platelets in thrombosis. Thrombosis et Diathesis Haemorrhagica, Suppl 42: 137.
    PubMedSuche in Google Scholar
  • 6 Hugues J, and Lapière C. M. 1964; Nouvelles recheres sur l’accolement des plaquettes aux fibres de collagène. Thrombosis et Diathesis Haemorrhagica 11: 327.
    PubMedSuche in Google Scholar
  • 7 Jamieson G. A, Urban C, and Barber A. J. 1971 An enzymatic basis for platelet-collagen-adhesion. Abstract volume II. International Congress on Thrombosis and Haemostasis, Oslo, p. 220.
    PubMedSuche in Google Scholar
  • 8 Johnson S. A. 1971. Endothelial supporting function of platelets. In: Johnson S. A. (ed.) Circulating Platelet. Academic Press; New-York, London: 283.
    Suche in Google Scholar
  • 9 Marr J, Barboriak J. J, and Johnson S. A. 1965; Relationship of appearance of adenosine diphosphate, fibrin formation and platelet aggregation in the haemostatic plug in vivo. Nature 205: 259.
    CrossrefPubMedSuche in Google Scholar
  • 10 Vinazzer H. 1972. Gerinnungsstörungen in der Praxis. G. Fischer Verlag; Stuttgart: 2.
    Suche in Google Scholar
  • 11 Zucker M. B. 1947; Platelet agglutination and vasoconstriction as factors in spontaneous haemostasis in normal, thrombocytopenic, heparinized and hypothrombinemic rats. American Journal of Physiology 148: 275.
    PubMedSuche in Google Scholar