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Thromb Haemost 1973; 30(03): 460-470
DOI: 10.1055/s-0038-1649124
Original Article
Schattauer GmbH

Further Evidence for a Humoral Control of Factor VIII Plasma Levels

Ricardo H. Landaburu
1   Laboratorio de Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina
,
Delicia E. Castellanos
1   Laboratorio de Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina
› Author Affiliations
Further Information

Publication History

Received 20 July 1973

Accepted 14 August 1973

Publication Date:
30 June 2018 (online)

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Summary

Factor VIII increase after stress or adrenergic stimulation appears to be justified by ACTH release, which in turn liberates a principle other than steroids, from the adrenal cortex. A substance isolated from adrenal cortex and denominated S3 increase, when injected, the level of plasma factor VIII. The rise in factor VIII after S3 also occurs in adrenalectomized animals where ACTH or catecholamines administration gives negative results.

 

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