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Thromb Haemost 1973; 30(03): 460-470
DOI: 10.1055/s-0038-1649124
Original Article
Schattauer GmbH

Further Evidence for a Humoral Control of Factor VIII Plasma Levels

Ricardo H. Landaburu
1   Laboratorio de Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina
,
Delicia E. Castellanos
1   Laboratorio de Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina
› Institutsangaben
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Publikationsverlauf

Received 20. Juli 1973

Accepted 14. August 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

Factor VIII increase after stress or adrenergic stimulation appears to be justified by ACTH release, which in turn liberates a principle other than steroids, from the adrenal cortex. A substance isolated from adrenal cortex and denominated S3 increase, when injected, the level of plasma factor VIII. The rise in factor VIII after S3 also occurs in adrenalectomized animals where ACTH or catecholamines administration gives negative results.

 

  • References

  • 1 Casillas G, Simonetti C, and Pavlovsky A. 1970; Molecular seaving experiments on human factor VIII. Coagulation 3: 123.
    PubMedSuche in Google Scholar
  • 2 Dodds W. J. 1969; a Hepatic influence on splenic synthesis and release of coagulation activities. Science 166: 882.
    CrossrefPubMedSuche in Google Scholar
  • 3 Dodds W. J. 1969; b Storage, release, and synthesis of coagulation factors in isolated perfused organs. American Journal of Physiology 217: 879.
    PubMedSuche in Google Scholar
  • 4 Dodds W. H, and Miller K. D. 1968; Storage and synthesis of coagulation factors in the isolated perfused liver, kidney and spleen. Federation Proceedings 27: 2.
    PubMedSuche in Google Scholar
  • 5 Duckert F, and Koller F. 1964. Estimation of factor X (Stuart-Prower) activity. In: Tocantins L. M, and Kazal L. A. (eds.) Blood Coagulation, Hemorrhage and Thrombosis. Methods of Study. Grune & Stratton; New York: 129.
    Suche in Google Scholar
  • 6 Egeberg O. 1963; On the nature of the blood antihemophilic A factor (AHA = F. VIII) increase associated with muscular exercise. The Scandinavian Journal of Clinical and Laboratory Investigation 15: 202.
    PubMedSuche in Google Scholar
  • 7 Forwell G. D, and Ingram G. I. C. 1957; The effect of adrenaline infusion on human blood coagulation. Journal of Physiology 135: 371.
    CrossrefPubMedSuche in Google Scholar
  • 8 Gardikas C, Bakaloudis P, Hatzioannou J, and Kokkinos D. 1965; The factor-VIII concentration of the hepatic venous blood. British Journal of Haematology 11: 380.
    CrossrefPubMedSuche in Google Scholar
  • 9 Goudemand M, FoucAUT M, Habay D, et Parquet-Gernez A. 1964; Les variations du taux de facteur VIII au cours de l’exercice musculaire. Essai d’interprétation. Nouvelle Revue Française d’Hématologie 4: 315.
    PubMedSuche in Google Scholar
  • 10 Gunn C. G, and Hampton J. W. 1967; CNS influence on plasma levels of factor VIII activity. American Journal of Physiology 212: 124.
    PubMedSuche in Google Scholar
  • 11 Hathaway W. E, Mull M. M, Githens J. H, Groth C. G, Marchioro T. L, and Starzl T. E. 1969; Attempted spleen transplant in classical hemophilia. Transplantation 7: 73.
    PubMedSuche in Google Scholar
  • 12 Iatrides S. G, and Ferguson J. M. 1963; Effect of physical exercise on blood clotting and fibrinolysis. Journal of Applied Physiology 18: 337.
    CrossrefPubMedSuche in Google Scholar
  • 13 Ingram G. I. C. 1961; Increase in antihaemophilic globulin activity following infusion of adrenaline. Journal of Physiology 156: 217.
    CrossrefPubMedSuche in Google Scholar
  • 14 Ingram G. I. C, and Vaughan Jones PL. 1966; The rise in clotting factor VIII induced in man by adrenaline: Effect of α-and β-blockers. Journal of Physiology 187: 447.
    CrossrefPubMedSuche in Google Scholar
  • 15 Kappeler R. 1965; Das Verhalten von Faktor V in Serum unter normalen und pathologischen Bedingungen. Zeitschrift für klinische Medizin 153: 103.
    PubMedSuche in Google Scholar
  • 16 Kelly G, Pechet L, and Eiseman B. 1970; Synthesis of antihemophilic globulin by the isolated perfused spleen. Surgery, Gynecology & Obstetrics 131: 473.
    PubMedSuche in Google Scholar
  • 17 Kingsley G. R, and Getchell G. 1961; A simple method for the determination of urinary adrenocortical steroids (α-Ketols). Analytical Biochemistry 2: 1.
    CrossrefPubMedSuche in Google Scholar
  • 18 Lambilliotte J. P, Sise H. S, et Norman J. C. 1968; Libération de facteur VIII (A.H.F.) par la rate isolée de porc et perfusée par du sang humain hémophilique. Revue Française d’Etudes Cliniques et Biologiques 13: 395.
    PubMedSuche in Google Scholar
  • 19 Landaburu R. H, Bengio R. H, and Castellanos D. E. (in press): The humoral regulation of factor VIII plasma levels. In: Medicine. Proceedings of the VIII Congress of the World Federation of Hemophilia, Buenos Aires, 24-27 July 1972.
    PubMed
  • 20 Landaburu R. H, and Castellanos D. E. 1972; a Neurohumoral control of blood coagulation: Participation of the adrenal glands. New Istanbul Contribution to Clinical Science 10: 113.
    PubMedSuche in Google Scholar
  • 21 Landaburu R. H, and Castellanos D. E. 1972; b Neurohumoral control of blood coagulation: Adrenergic stimulation and spleen in the control of factor VIII plasma level. New Istanbul Contribution to Clinical Science 10: 121.
    PubMedSuche in Google Scholar
  • 22 Landaburu R. H, Castellanos D. E, Giavedoni E, and Lo Presti C. A. 1971; a Neurohumoral control of blood coagulation. I. Effects of adrenergic drugs or ACTH administration and stress. Acta Physiologica Latino Americana 21: 64.
    PubMedSuche in Google Scholar
  • 23 Landaburu R. H, Lo Presti C. A, Hillar M. A, and Castellanos D. E. 1971; b Neurohumoral control of blood coagulation II. Participation of Hypothalamus and hypophysis. Acta Physiologica Latino Americana 21: 74.
    PubMedSuche in Google Scholar
  • 24 Libre E. P, Cowan D. H, Watkins Jr. S. P, and Shulman N. R. 1968; Relationships between spleen, platelets and factor VIII levels. Blood 31: 358.
    PubMedSuche in Google Scholar
  • 25 Mannucci P. M, Ruggeri Z. M, and Gagnatelli G. 1971; Nervous regulation of factor-VIII levels in man. British Journal of Haematology 20: 195.
    CrossrefPubMedSuche in Google Scholar
  • 26 Margolis J. 1958; The kaolin clotting time. A rapid one-stage method for diagnosis of coagulation defects. Journal of Clinical Pathology 11: 406.
    CrossrefPubMedSuche in Google Scholar
  • 27 McKee P. A, Coussons R. T, Buckner R. G, Williams G. R, and Hampton J. W. 1970; Effects of the spleen on canine factor VIII levels. The Journal of Laboratory and Clinical Medicine 75: 391.
    PubMedSuche in Google Scholar
  • 28 Norman J. C, Lambilliotte J.-P, Kojima Y, and Sise H. S. 1967; Antihemophilic factor release by perfused liver and spleen: Relationship to hemophilia. Science 158: 1060.
    CrossrefPubMedSuche in Google Scholar
  • 29 Pool J. G, and Spaet T. H. 1954; Ethionine-induced depression of plasma antihemophilic globulin in the rat. Proceedings of the Society for Experimental Biology and Medicine 87: 54.
    PubMedSuche in Google Scholar
  • 30 Pudlak P, Farsea I, and Deimlova E. 1969; Changes in factors V and VIII after administration of adrenaline to normal and splenectomized rats. British Journal of Haematology 16: 373.
    CrossrefPubMedSuche in Google Scholar
  • 31 Pudlak P, FaPvSKA I, Horak J, et Deimlova E. 1968; Changements de l’activité de la globuline antihémophilique (facteur VIII) après administration d’adrénaline aux malades avec affections du système reticuloendothelial. Nouvelle Revue Française d’Hématologie 8 (24) 1.
    PubMedSuche in Google Scholar
  • 32 Ratnoff O. D, and Menzie C. 1951; A new method for the determination of fibrinogen in small samples of plasma. Journal of Laboratory and Clinical Medicine 37: 316.
    PubMedSuche in Google Scholar
  • 33 Rizza C. R, and Elpe J. 1971; Exercise, factor VIII and the spleen. British Journal of Haematology 20: 629.
    CrossrefPubMedSuche in Google Scholar
  • 34 Seegers W. H, and Ware A. G. 1949; Two stage procedure for the quantitative determination of prothrombin concentration. American Journal of Clinical Pathology 19: 471.
    CrossrefPubMedSuche in Google Scholar
  • 35 Von Euler U. S, and Lishanjko F. 1959; The estimation of catecholamines in the urine. Acta Physiologica Scandinavica 45: 122.
    CrossrefPubMedSuche in Google Scholar
  • 36 Weaver R. A, Price R. E, and Langdell R. D. 1964; Antihemophilic factor in cross-circulated normal and hemophilic dogs. American Journal of Physiology 206: 335.
    PubMedSuche in Google Scholar
  • 37 Webster W. P, Reddick R. L, Roberts H. R, and Penick G. D. 1967; Release of factor VIII (antihaemophilic factor) from perfused organs and tissues. Nature 213: 1146.
    CrossrefPubMedSuche in Google Scholar