Influence of Platelet Count on Haemostatic Plug Formation and Plug Stability

D Bergqvist; K.-E Arfors

doi:10.1055/s-0038-1649137

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(03): 586-596
DOI: 10.1055/s-0038-1649137

Original Article

Schattauer GmbH

Influence of Platelet Count on Haemostatic Plug Formation and Plug Stability

An Experimental Study in Rabbits with Graded Thrombocytopenia

D Bergqvist

¹Department of Experimental Medicine, Pharmacia AB

²Department of Surgery, University Hospital, Uppsala, Sweden

,

K.-E Arfors

¹Department of Experimental Medicine, Pharmacia AB

²Department of Surgery, University Hospital, Uppsala, Sweden

› Author Affiliations

Abstract

Summary

The initial haemostatic process in thrombocytopenic animals after transection of arterioles and venules was investigated in a rabbit mesenteric preparation. Graded thrombocytopenia with a bone marrow suppressant (busulphan) and anti-platelet serum gave comparable results. With decreasing platelet counts there was progressive prolongation in haemostatic plug formation time, and a significant non-linear relation between platelet count and haemostatic plug formation time. Haemostatic plugs formed under thrombocytopenic conditions were more stable than normal. The difference in stability normally seen between plugs in arterioles and venules disappeared with decreasing platelet counts. The relationship between venular and arteriolar haemostatic plug formation time was also reduced with decreasing platelet counts.

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References

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