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Thromb Haemost 1973; 30(03): 586-596
DOI: 10.1055/s-0038-1649137
Original Article
Schattauer GmbH

Influence of Platelet Count on Haemostatic Plug Formation and Plug Stability

An Experimental Study in Rabbits with Graded Thrombocytopenia
D Bergqvist
1   Department of Experimental Medicine, Pharmacia AB
2   Department of Surgery, University Hospital, Uppsala, Sweden
,
K.-E Arfors
1   Department of Experimental Medicine, Pharmacia AB
2   Department of Surgery, University Hospital, Uppsala, Sweden
› Author Affiliations
Further Information

Publication History

Received 22 June 1973

Accepted 28 August 1973

Publication Date:
24 July 2018 (online)

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Summary

The initial haemostatic process in thrombocytopenic animals after transection of arterioles and venules was investigated in a rabbit mesenteric preparation. Graded thrombocytopenia with a bone marrow suppressant (busulphan) and anti-platelet serum gave comparable results. With decreasing platelet counts there was progressive prolongation in haemostatic plug formation time, and a significant non-linear relation between platelet count and haemostatic plug formation time. Haemostatic plugs formed under thrombocytopenic conditions were more stable than normal. The difference in stability normally seen between plugs in arterioles and venules disappeared with decreasing platelet counts. The relationship between venular and arteriolar haemostatic plug formation time was also reduced with decreasing platelet counts.

 

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