Frequency of Antibodies Directed against Heparin-Platelet Factor 4 in Patients Exposed to Heparin through Chronic Hemodialysis

Thromb Haemost 1996; 75(04): 695-696
DOI: 10.1055/s-0038-1650347

Letter to the Editor

Schattauer GmbH Stuttgart

M de Sancho

¹Dept. of Hematology, Mount Sinai Medical Center, New York, USA

,

M G Lema

¹Dept. of Hematology, Mount Sinai Medical Center, New York, USA

,

J Amiral

²Serbio Laboratories, Gennevilliers, France

,

J Rand

¹Dept. of Hematology, Mount Sinai Medical Center, New York, USA

References
1 Warkentin T, Kelton J. Heparin-induced thrombocytopenia. Progr Haemostas Thrombosis 1991; 10: 1-34
2 Amiral J, Bridey F, Dreyfus M, Vissac A, Fressinaud E, Wolf M, Meyer D. Platelet Factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992; 68: 95
3 Gruel Y, Boizard-Boval B, Wautier JL. Further evidence that a granule components such as PF4 are involved in platelet-IgG heparin interactions during heparin-associated thrombocytopenia. Thromb Haemost 1993; 68: 374-375
4 Amiral J, Bridey F, Dreyfus M, Vissac AM, Fressinaud E, Meyer D. Identification of PF4 as a target for antibodies generated in heparin induced thrombocytopenia. Development of a diagnostic test. Thromb Haemost 1991; 65: 865 (Abstract)