Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1968; 20(03/04): 465-468DOI: 10.1055/s-0038-1651289 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH Investigation of the Apparent Thrombogenicity of Thrombin[*] E. T Yin 1 Department of Medicine, The Jewish Hospital of St. Louis, and the Washington University School of Medicine, St. Louis, Missouri 63110 , S Wessler 1 Department of Medicine, The Jewish Hospital of St. Louis, and the Washington University School of Medicine, St. Louis, Missouri 63110 › Author Affiliations Recommend Article Abstract PDF Download Buy Article Summary This investigation demonstrates that most of the thrombogenic effect of small amounts of commercial thrombin is not dependent upon the calculated units of infused thrombin but rather upon its contamination with activated factor X. These data also reflect the need to re-evaluate the biologic effects attributed to thrombin itself in various studies in which thrombin preparations contaminated with activated factor X have been employed. PDF (567 kb) References References 1 Duckert F, Streuli F. Role of Coagulation in Thrombosis. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl 1966; 21: 185 2 Wessler S. Studies in Intravascular Coagulation. III. The Pathogenesis of Serum-Induced Venous Thrombosis. J. clin. Invest 1955; 34: 647 3 Wessler S, Reimer S.M, Sheps M.D. Biologic Assay of a Thrombosis-Inducing Activity in Human Serum. J. appl. Physiol 1960; 14: 262 4 Wessler S, Yin E.T, Gaston L.W, Nicol I. A Distinction Between the Role of Precursor and Activated Forms of Clotting Factors in the Genesis of Stasis Thrombi. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 18: 12 5 Wessler S, Yin E.T. The Experimental Hyper coagulable State Induced by Factor X: A Comparison of the Non-Activated and Activated Forms. J. Lab. clin. Med 1968; 72: 256 6 Yin E.T, Wessler S. Bovine Thrombin and Activated Factor X : Separation and Purification. J. biol. Chem 1968; 243: 112 7 Bell W.N, Alton H.G. A Brain Extract as a Substitute for Platelet Suspensions in the Thromboplastin Generation Test. Nature (Lond.) 1954; 174: 880 8 Cole E.E, Koppel J.L, Olwin J.H. Autoprothrombin C from a Commercial Thrombin Product. Nature (Lond.) 1964; 202: 301 9 Barton P.G, Jackson C.M, Hanahan D.J. Relationship Between Factor V and Activated Factor X in the Generation of Prothrombinase. Nature (Lond.) 1967; 214: 923
