Plasma Fibrinolytic Activity Following Oral Anabolic Steroid Therapy

I. D Walker; J. F Davidson; P Young; J. A Conkie

doi:10.1055/s-0038-1651371

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1975; 34(01): 236-245
DOI: 10.1055/s-0038-1651371

Original Article

Schattauer GmbH

Plasma Fibrinolytic Activity Following Oral Anabolic Steroid Therapy

Authors

I. D Walker

¹Department of Haematology, Royal Infirmary, Glasgow
J. F Davidson

¹Department of Haematology, Royal Infirmary, Glasgow
P Young

¹Department of Haematology, Royal Infirmary, Glasgow
J. A Conkie

¹Department of Haematology, Royal Infirmary, Glasgow

Abstract

Summary

Six anabolic steroids were assessed for their ability to enhance plasma fibrinolytic activity in males with ischaemic heart disease. Five 17α-alkylated steroids (Ethyloestrenol, Norethandrolone, Methandienone, Methylandrostenediol and Oxymetholone) were examined and all produced a significant increase in plasma plasminogen activator as measured by the euglobulin lysis time. The only non-17α-alkylated steroid studied (Methenolone acetate) failed to enhance fibrinolysis. The 17α-alkylated steroids studied all deserve more detailed evaluation of their long term effects on plasma fibrinolytic activity.

Full Text

References

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