Senologie - Zeitschrift für Mammadiagnostik und -therapie 2018; 15(02): e28
DOI: 10.1055/s-0038-1651749
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer – A systematic review

, , Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
D Krug
1   Universitätsklinikum Heidelberg, Radioonkologie und Strahlentherapie, Heidelberg, Deutschland
2   National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Deutschland
,
R Baumann
3   University Hospital Schleswig-Holstein, Kiel, Deutschland
,
W Budach
4   Heinrich-Heine-University, Düsseldorf, Deutschland
,
J Dunst
3   University Hospital Schleswig-Holstein, Kiel, Deutschland
,
P Feyer
5   Vivantes Hospital Neukölln, Berlin, Deutschland
,
R Fietkau
6   University Hospital Erlangen, Erlangen, Deutschland
,
W Haase
7   Formerly St. Vincentius-Hospital, Karlsruhe, Deutschland
,
T Hehr
8   Marienhospital Stuttgart, Stuttgart, Deutschland
,
MD Piroth
9   University Witten/Herdecke, HELIOS-Hospital Wuppertal, Wuppertal, Deutschland
,
F Sedlmayer
10   Paracelsus Medical University Hospital, Salzburg, Österreich
,
R Souchon
11   Formerly University Hospital Tübingen, Tübingen, Deutschland
,
F Wenz
12   University Hospital Mannheim, Mannheim, Deutschland
,
R Sauer
6   University Hospital Erlangen, Erlangen, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
22 May 2018 (online)

Also available at
 

Introduction:

To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer with a special focus on individualization of adjuvant radiotherapy based on treatment response.

Methods:

A systematic literature research using the PubMed/Medline-database was performed. We included prospective and retrospective reports with a minimum of 10 patients that were published since 1st January 2000 and provided clinical outcome data analyzed by treatment response and radiotherapy.

Results:

Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports.

Conclusion:

There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B-51/RTOG 1304 and Alliance A11202 are eagerly awaited.