Senologie - Zeitschrift für Mammadiagnostik und -therapie 2018; 15(02): e28
DOI: 10.1055/s-0038-1651749
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer – A systematic review

Authors

    , , Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)

  • D Krug

    1   Universitätsklinikum Heidelberg, Radioonkologie und Strahlentherapie, Heidelberg, Deutschland
    2   National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Deutschland

  • R Baumann

    3   University Hospital Schleswig-Holstein, Kiel, Deutschland

  • W Budach

    4   Heinrich-Heine-University, Düsseldorf, Deutschland

  • J Dunst

    3   University Hospital Schleswig-Holstein, Kiel, Deutschland

  • P Feyer

    5   Vivantes Hospital Neukölln, Berlin, Deutschland

  • R Fietkau

    6   University Hospital Erlangen, Erlangen, Deutschland

  • W Haase

    7   Formerly St. Vincentius-Hospital, Karlsruhe, Deutschland

  • T Hehr

    8   Marienhospital Stuttgart, Stuttgart, Deutschland

  • MD Piroth

    9   University Witten/Herdecke, HELIOS-Hospital Wuppertal, Wuppertal, Deutschland

  • F Sedlmayer

    10   Paracelsus Medical University Hospital, Salzburg, Österreich

  • R Souchon

    11   Formerly University Hospital Tübingen, Tübingen, Deutschland

  • F Wenz

    12   University Hospital Mannheim, Mannheim, Deutschland

  • R Sauer

    6   University Hospital Erlangen, Erlangen, Deutschland
Further Information

Publication History

Publication Date:
22 May 2018 (online)

Also available at
 
 

    Introduction:

    To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer with a special focus on individualization of adjuvant radiotherapy based on treatment response.

    Methods:

    A systematic literature research using the PubMed/Medline-database was performed. We included prospective and retrospective reports with a minimum of 10 patients that were published since 1st January 2000 and provided clinical outcome data analyzed by treatment response and radiotherapy.

    Results:

    Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports.

    Conclusion:

    There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B-51/RTOG 1304 and Alliance A11202 are eagerly awaited.