Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer – A systematic review

D Krug; R Baumann; W Budach; J Dunst; P Feyer; R Fietkau; W Haase; T Hehr; MD Piroth; F Sedlmayer; R Souchon; F Wenz; R Sauer

doi:10.1055/s-0038-1651749

Senologie - Zeitschrift für Mammadiagnostik und -therapie, Table of Contents

Senologie - Zeitschrift für Mammadiagnostik und -therapie 2018; 15(02): e28
DOI: 10.1055/s-0038-1651749

Abstracts

Georg Thieme Verlag KG Stuttgart · New York

Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer – A systematic review

, , Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)

D Krug

¹Universitätsklinikum Heidelberg, Radioonkologie und Strahlentherapie, Heidelberg, Deutschland

²National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Deutschland

,

R Baumann

³University Hospital Schleswig-Holstein, Kiel, Deutschland

,

W Budach

⁴Heinrich-Heine-University, Düsseldorf, Deutschland

,

J Dunst

³University Hospital Schleswig-Holstein, Kiel, Deutschland

,

P Feyer

⁵Vivantes Hospital Neukölln, Berlin, Deutschland

,

R Fietkau

⁶University Hospital Erlangen, Erlangen, Deutschland

,

W Haase

⁷Formerly St. Vincentius-Hospital, Karlsruhe, Deutschland

,

T Hehr

⁸Marienhospital Stuttgart, Stuttgart, Deutschland

,

MD Piroth

⁹University Witten/Herdecke, HELIOS-Hospital Wuppertal, Wuppertal, Deutschland

,

F Sedlmayer

¹⁰Paracelsus Medical University Hospital, Salzburg, Österreich

,

R Souchon

¹¹Formerly University Hospital Tübingen, Tübingen, Deutschland

,

F Wenz

¹²University Hospital Mannheim, Mannheim, Deutschland

,

R Sauer

⁶University Hospital Erlangen, Erlangen, Deutschland

› Author Affiliations

Abstract

Full Text

Introduction:

To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer with a special focus on individualization of adjuvant radiotherapy based on treatment response.

Methods:

A systematic literature research using the PubMed/Medline-database was performed. We included prospective and retrospective reports with a minimum of 10 patients that were published since 1^st January 2000 and provided clinical outcome data analyzed by treatment response and radiotherapy.

Results:

Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports.

Conclusion:

There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B-51/RTOG 1304 and Alliance A11202 are eagerly awaited.