Quantitative Determination of Intravascular Coagulation in Vivo in Various Organs in the Dog

Ch Busch; H Lundqvist; T Saldeen

doi:10.1055/s-0038-1653679

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1971; 26(02): 315-324
DOI: 10.1055/s-0038-1653679

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Quantitative Determination of Intravascular Coagulation in Vivo in Various Organs in the Dog

Ch Busch

¹Department of Forensic Medicine, Institute of Pathology and Forensic Medicine and the Radiobiological Department, Gustaf Werner Institute, University of Uppsala, Uppsala, Sweden

,

H Lundqvist

¹Department of Forensic Medicine, Institute of Pathology and Forensic Medicine and the Radiobiological Department, Gustaf Werner Institute, University of Uppsala, Uppsala, Sweden

,

T Saldeen

¹Department of Forensic Medicine, Institute of Pathology and Forensic Medicine and the Radiobiological Department, Gustaf Werner Institute, University of Uppsala, Uppsala, Sweden

› Author Affiliations

Abstract

Summary

A technique for determination of intravascular coagulation in different organs by means of continuous external detection of ¹²⁵I-fibrinogen in the dog is described.

It is suggested that this technique would be of value in human beings as a complement to the present, often unsatisfactory methods for determination of microembolism.

Full Text

References

References
1 Arfors K. E, Busch G, Jakobsson S, Lindquist O, Malmberg P, Rammer L, Saldeen T. Pulmonary Insufficiency following Intravenous Injection of Thrombin and AMCA (tranexamic acid) in the Dog. Acta chir. scand. (In press.)
2 Blombäck B, Blombäck M. Purification of human and bovine fibrinogen. Arkiv Kemi 10: 415 1956;
3 Busch G, Rammer L, Saldeen T. Quantitation of fibrin deposition and elimination in various organs of rats injected with labelled fibrinogen and albumin. (To be published).
4 Clarkson A. R, McDonald M. K, Fuster V, Robson J. S, Gash J. D. Intravascular coagulation in acute ischaemic renal failure. Abstracts from VI Conference on Microcirculation. Central-Try kkeriet Offset, Aalborg. 1970
5 McKay D. G. Disseminated Intravascular Coagulation. An Intermediary Mechnism of Disease. Hoeber Medical Division. Harper & Row, Publishers: New York; 1965
6 Reba R. C, McAsee J. G, Wagner H. N. Radiomercury labelled chlormerodrin for in vivo uptake studies and scintillation scanning of unilateral renal lesions associated with hypertension. Medicine 42: 269 1963;
7 Rosa U, Scassellatti G. A, Pennis F. Labelling of human fibrinogen with ¹³¹1 by electrolytic iodination. Biochim. biophys. Acta (Amst) 86: 519 1964;
8 Saldeen T. Experimental investigation on fat embolism and intravascular coagulation. Acta path, microbiol. scand 66: 271 1966;
9 Saldeen T. Quantitative determination of intravascular coagulation in the lungs of experimental animals. Scand. J. Haemat 06: 206 1969;
10 Saldeen T, Busch C, Lindquist O, Rammer L. The Microembolism syndrome. Acta path, microbiol. scand. (In press.)