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DOI: 10.1055/s-0038-1653753
Incidence of Factor VIII Inhibitor Development in Severe Hemophilia A Patients Treated only with One Brand of Highly Purified Plasma-Derived Concentrate
Publikationsverlauf
Received 01. August 1994
Accepted after resubmission 18. Oktober 1994
Publikationsdatum:
09. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199502/lookinside/thumbnails/10-1055-s-0038-1653753-1.jpg)
Summary
The incidence of factor VIII inhibitor was studied in a cohort of 56 previously untreated patients with severe hemophilia A (factor VIII below 1 U/dl). They received only one brand of highly purified factor VIII concentrate (HPSD-VIII) prepared by conventional chromatography with a solvent-detergent step for viral inactivation. Followup since the first infusion of HPSD-VIII was from 1 to 76 months (mean = 29) and cumulative exposure days (CED) from 1 to over 100 (median = 26). Five patients (9%) developed an inhibitor after 6 to 19 CED, only one being a high responder (2%), showing a low incidence of inhibitor compared with previous studies using high purity plasma- derived or recombinant products.
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