Dietary Changes in Fasting Levels of Factor VII Coagulant Activity (FVII: C) Are Accompanied by Changes in Factor VII Protein and other Vitamin K-dependent Proteins

E M Bladbjerg; T Tholstrup; P Marckmann; B Sandström; J Jespersen

doi:10.1055/s-0038-1653757

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 73(02): 239-242
DOI: 10.1055/s-0038-1653757

Original Article

Coagulation

Schattauer GmbH Stuttgart

Dietary Changes in Fasting Levels of Factor VII Coagulant Activity (FVII: C) Are Accompanied by Changes in Factor VII Protein and other Vitamin K-dependent Proteins

E M Bladbjerg

¹The Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, and Department of Clinical Biochemistry, Ribe County Hospital in Esbjerg, Denmark

,

T Tholstrup

²The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

,

P Marckmann

²The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

,

B Sandström

²The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

,

J Jespersen

¹The Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, and Department of Clinical Biochemistry, Ribe County Hospital in Esbjerg, Denmark

› Author Affiliations

Abstract

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Summary

The mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII: C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks each. Fasting blood samples were collected before and after the dietary regimen and analysed for triglycerides, FVII:C, and protein concentrations of FVII, FII, FX, protein C, CRP, albumin, fibrinogen, and F1+2. FVII:C was significantly reduced on diet S compared with diet ML. This was accompanied by a decrease in FVII protein, F1+2 and the vitamin K-dependent proteins FII, FX, and protein C. In contrast, no changes were observed in triglycerides, FVII:C/FVII: Ag, albumin and CRP. Fibrinogen was increased on diet S compared with diet ML. Our findings suggest that the change in fasting FVII:C was part of a general change in concentrations of vitamin K-dependent proteins.

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References

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