Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1967; 17(01/02): 156-164DOI: 10.1055/s-0038-1654090 Originalarbeiten - Original Articles - Travaux Originaux Schattauer GmbH Studies on the Pathogenesis of the Generalized Shwartzman Reaction IV: Production of a Shwartzman-like phenomenon with autoprothrombin-C F Rodríguez-Erdmann * 1 New England Medical Center Hospitals and Department of Medicine, Tufts -University School of Medicine, Boston , S Naimi 1 New England Medical Center Hospitals and Department of Medicine, Tufts -University School of Medicine, Boston › Author Affiliations Recommend Article Abstract Buy Article Summary Autoprothrombin-C (factor Xa) was given intravenously to rabbits whose RES had been previously blocked with thorotrast. The coagulo-analytical results as well as the morphological changes resemble those of the classical generalized Shwartzman reaction (gSr) produced by properly spaced doses of Gram-negative endotoxin. 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