Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1967; 17(01/02): 156-164DOI: 10.1055/s-0038-1654090 Originalarbeiten - Original Articles - Travaux Originaux Schattauer GmbH Studies on the Pathogenesis of the Generalized Shwartzman ReactionIV: Production of a Shwartzman-like phenomenon with autoprothrombin-CAuthors Author Affiliations F Rodríguez-Erdmann * 1 New England Medical Center Hospitals and Department of Medicine, Tufts -University School of Medicine, Boston S Naimi 1 New England Medical Center Hospitals and Department of Medicine, Tufts -University School of Medicine, Boston Recommend Article Abstract Buy Article(opens in new window) Summary Autoprothrombin-C (factor Xa) was given intravenously to rabbits whose RES had been previously blocked with thorotrast. The coagulo-analytical results as well as the morphological changes resemble those of the classical generalized Shwartzman reaction (gSr) produced by properly spaced doses of Gram-negative endotoxin. The results are discussed in the light of the literature. Full Text References References 1 Apitz K. A study of the generalized Shwartzman phenomenon. J. Immunol 29: 255-266 1953; 2 Beeson P. B. Effect of retículo-endothelial blockade on immunity to the Shwartzman phenomenon. Proc. Soc. exp. Biol. (N. Y.) 64: 146-149 1947; 3 Berken A, Wolman M. On the nature of the precipitate in the generalized Shwartzman reaction. J. Immunol 89: 490-495 1962; 4 Davie E. W, Ratnoff O. D. Waterfall sequence for intrinsic blood clotting. Science 145: 1310-1312 1964; 5 Feissly R, Lüdin H. Microscopie par contrastes de Phases. Rev. hémat 4: 481-501 1949; 6 Good R. A, Thomas L. Studies on the generalized Shwartzman reaction. II: The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with thorotrast or trypanblue. J. exp. Med 96: 625-641 1952; 7 Jarvis B. W, Schräder W. H, Brunson J. G. Influence of abdominal radiation on response of rabbits to intravenous endotoxin. Arch. Pathol 65: 561-569 1958; 8 Kleinmaier K, Georgen K, Lasch H. G, Krecke H. J, Bohle A. Untersuchungen zur Frage der Gerinnungsstörung beim Sanarelli-Shwartzman-Phänomen (sog. generalisierten Shwartz-man-Phänomen) des Kaninchens. Z. ges. exp. Med 132: 275-294 1959; 9 Kusama Sh. Über Aufbau und Entstehung der toxischen Thrombosen und deren Bedeutung. Ziegler’s Beitr. path. Anat 55: 459-544 1913; 10 Lee L. Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction. J. exp. Med 115: 1065-1082 1962; 11 Lee L. Mechanisms involved in the production of the generalized Shwartzman reaction. In: Bacterial Endotoxins. Edited by Landy M, Braun W. Rutgers Univ. Press; New Brunswick: 1964: 648-657. 12 Lee L, McCluskey R. T. Immunochemical demonstration of the reticuloendothelial clearance of circulating fibrin aggregates. J. exp. Med 116: 611-618 1962; 13 MacFarlane R. G. The coagulant action of Russell’s viper venom, the use of antivenom in defining its reaction with a serum factor. Brit. J. Haemat 7: 496-511 1961; 14 MacFarlane R. G. An enzyme cascade in blood clotting mechanism and its functions as a biochemical amplifier. Nature (Lond.) 202: 498-499 1964; 15 Marciniak E. Autoprothrombin-activates in serum. Bull. Acad. poi. Sci 9: 381-385 1961; 16 Marciniak E, Rodriguez-Erdmann F, Seegers W. H. Toxicity of blood clotting factors. Science 137: 421-422 1962; 17 Marciniak E, Seegers W. H. Autoprothrombin-C: a second enzyme from prothrombin. Canad. J. Biochem 40: 597-605 1962; 18 McKay D. G. A partial synthesis of the generalized Shwartzman reaction. Fed. Proc 22: 1373-1379 1963; 19 Milstone J. H, Oulianoff N, Müstone V. K. Outstanding characteristics of thrombokinase isolated from bovine plasma. J. gen. Physiol 47: 315-327 1963; 20 Morawitz P. Die Chemie der Blutgerinnung. Ergebn. Physiol 4: 307-422 1905; 21 Nemerson Y, Spaet T. The activation of factor X by extracts of rabbit brain. Blood 23: 657-668 1964; 22 Poole J. G. F. Fats and blood coagulation. Brit. med. Bull 14: 253-257 1958; 23 Prose Ph. H, Lee L, Balk S. D. Electron-microscopic study of the phagocytic fibrin clearing mechanism. Amer. J. Pathol 47: 403-417 1965; 24 Quick A. J. Hemorrhagic diseases. Lea & Feabiger; Philadelphia: 1957: 437. 25 Rodríguez-Erdmann F. Über eine einfache Methode zur wiederholten Blutgewinnung beim Kaninchen. Pflüger’s Archiv ges. Physiol 269: 306-307 1959; 26 Rodríguez-Erdmann F. Studies on the pathogenesis of the generalized Shwartzman reaction. I : Alterations in the coagulation system during the generalized Shwartzman reaction of the pregnant rabbit. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 452-461 1964; 27 Rodríguez-Erdmann F. Studies on the pathogenesis of the generalized Shwartzman reaction. II: Rôle played by experimentally induced fibrinolysis. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 462-470 1964; 28 Rodríguez-Erdmann F. Studies on the pathogenesis of the generalized Shwartzman reaction. III: Trigger mechanism for the activation of the prothrombin molecule. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 471-483 1964; 29 Rodríguez-Erdmann F. Blood clotting system in the pathogenesis of the Sanarelli-Shwartzman reaction. Experientia (Basel) 20: 223-224 1964; 30 Rodríguez-Erdmann F. Pathogenesis of bilateral renal cortical necrosis: its production by means of exogenous fibrin. Arch. Pathol 79: 615-618 1965; 31 Rodríguez-Erdmann F. Intravascular activation of the clotting system with phospholipids. Production of the generalized Shwartzman reaction with platelet-factor 3. Blood 26: 541-553 1965; 32 Rodríguez-Erdmann F. Bleeding due to increased intravascular blood coagulation: Hemorrhagic syndromes caused by consumption of blood clotting factors (consumption-coagulo-pathies). New Engl. J. Med 273: 1370-1378 1965; 33 Rodríguez-Erdmann F, Krecke H. J, Lasch H. G, Bohle A. Über die morphologischen und gerinnungsanalytischen Veränderungen nach Liquoid. Ein Beitrag zur Pathogenese des Sanarelli-Shwartzman-Phänomens. Z. ges. exp. Med 134: 109-130 1960; 34 Sanarelli G. Le choléra expérimental. Ann. Inst. Pasteur 38: 11-71 1924; 35 Seegers W. H. Prothrombin. Harvard University Press; Cambridge (Mass.): 1962 36 Seegers W. H. Basic enzymology of blood coagulation. Thrombos. Diathes. haemorrh. (Stuttg.) 14: 213-228 1965; 37 Seegers W. H, Gole E. R, Harmison G. R, Marciniak E. Purification and some properties of autoprothrombin-C. Canad. J. Biochem 41: 1047-1063 1963; 38 Seegers W. H, Smith H. P. The purification of prothrombin. J. biol. Chem 140: 677-678 1941; 39 Smith R. T, Thomas L, Good R. A. Generalized Shwartzman reaction. V: Intravenous injection of colloidal iron or carbon in responce of rabbits to meningococcal toxin. Proc. Soc. exp. Biol. (N. Y.) 82: 712-715 1953; 40 Spaet T, Cintón J. Clearance of blood coagulation product I in rabbits. Proc. Soc. exp. Biol. (N. Y.) 104: 498-500 1960; 41 Thomas L. The rôle of the reticuloendothelial system in the reaction to endotoxins. In: Physiopathology of the retículo-endothelial system. Edited by Halpern B. N, Benacerraf B, & Delafresnaye J. F. Blackwell; Oxford: 1957: 226-244. 42 Thomas L, Good R. A. The effect of cortisone on the Shwartzman reaction. J. exp. Med 95: 409-427 1952;
