“Inhibitor Like” Effects of Hematoporphyrin on Factor VIII (Antihaemophilic Globulin)

R. B Davis; Rosemary Biggs; K. W. E Denson

doi:10.1055/s-0038-1654154

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1967; 17(03/04): 299-306
DOI: 10.1055/s-0038-1654154

Originalarbeiten - Original Articles - Travaux Originaux

Schattauer GmbH

“Inhibitor Like” Effects of Hematoporphyrin on Factor VIII (Antihaemophilic Globulin)

R. B Davis^*

¹Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Headington, Oxford

,

Rosemary Biggs

¹Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Headington, Oxford

,

K. W. E Denson

¹Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Headington, Oxford

› Author Affiliations

Abstract

Summary

The incubation of factor VIII with HP resulted in a progressive loss of factor VIII activity which was dependent on the porphyrin concentration. The rate of reaction was retarded by fibrinogen and glyoxaline, but was not accelerated by reduction in fibrinogen concentration. No increase in factor VIII activity was found when fibrinogen was added after destruction of factor VIII by HP, suggesting irreversibility of factor VIII destruction. The reaction was light but not temperature dependent; in other respects it closely resembled the kinetics observed during factor VIII destruction by naturally occurring anticoagulants and antibody inhibitors of factor VIII.

Full Text

References

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