Study of Thrombin-Coagulase

J. P Soulier; Odette Prou-Wartelle; Liliane Hallé; with the technical assistance of

doi:10.1055/s-0038-1654156

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1967; 17(03/04): 321-334
DOI: 10.1055/s-0038-1654156

Originalarbeiten - Original Articles - Travaux Originaux

Schattauer GmbH

Study of Thrombin-Coagulase

J. P Soulier

¹Centre National de Transfusion Sanguine, Paris

,

Odette Prou-Wartelle

¹Centre National de Transfusion Sanguine, Paris

,

with the technical assistance of,

Liliane Hallé

¹Centre National de Transfusion Sanguine, Paris

› Author Affiliations

Abstract

Summary

The preparation of thrombin-coagulase is described. The properties of thrombin-coagulase are compared with those of biothrombin: kinetics, thermostability, adsorption, chromatography, esterase activity, clotting activity, action on platelets and on factors V and VIII, susceptibility to inhibitors.

Biothrombin and thrombin-coagulase are closely related but distinct. Both apparently derive from prothrombin. Prothrombin and coagulase combine to form a complex: thrombin-coagulase wherein both factors are necessary for its activity. Possible explanations for the difference between thrombin-coagulase and biothrombin are proposed.

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References

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