Spontaneous Hemorrhage in Anticoagulant-Treated Rats when Subjected to Excitant or Depressant Drugs^[*]

Summary

Rats were given the convulsant drugs, Picrotoxin or Metrazol intraperitoneally, and then fed with food containing the anticoagulant, phenylindanedione (Danilone) for 10 days. Other rats received for 10 days food containing Phenylindanedione and depressant drugs (Nembutal, Barbitone, Librium or chlorpromazine). All combinations of drugs but not the single drugs produced a high incidence of internal hemorrhage, which was fatal to some animals.

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