The Clot-Promoting Effect of Adenosine-5’-Diphosphate (ADP). II. Site of Action

J Pizzuto; P Didisheim; Th. C Bithell

doi:10.1055/s-0038-1654182

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1967; 17(03/04): 578-584
DOI: 10.1055/s-0038-1654182

Originalarbeiten - Original Articles - Travaux Originaux

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The Clot-Promoting Effect of Adenosine-5’-Diphosphate (ADP). II. Site of Action^[*]

J Pizzuto^**

¹Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah, U.S.A.

,

P Didisheim^***

¹Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah, U.S.A.

,

Th. C Bithell

¹Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah, U.S.A.

› Author Affiliations

Abstract

Summary

1. ADP accelerates the rate of the “contact” phase of thromboplastin generation by a mechanism which is independent of its known effects on platelets.

2. The acceleratory effect is the result of an interaction between ADP and a plasma factor which is not clearly identifiable with any generally recognized coagulation factor (i. e., factors I-XIII).

Full Text

References

References
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The Clot-Promoting Effect of Adenosine-5’-Diphosphate (ADP). II. Site of Action[*]

The Clot-Promoting Effect of Adenosine-5’-Diphosphate (ADP). II. Site of Action^[*]