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Thromb Haemost 1970; 24(03/04): 338-344
DOI: 10.1055/s-0038-1654242
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Activation of Factor X in Bovine Prothrombin Preparations[*]

R. H Landaburu
1   Institute of Pharmacology, National University of Cόrdoba, Cόrdoba, Argentina
,
Emilia Albado
1   Institute of Pharmacology, National University of Cόrdoba, Cόrdoba, Argentina
› Institutsangaben
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Publikationsdatum:
24. Juli 2018 (online)

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Summary

Chromatographic fractionation of factor X (autoprothrombin III) and factor Xa (autoprothrombin C), obtained from bovine prothrombin preparations, on amberlite IRC-50 demonstrates activation of factor X under the conditions of prothrombin activation. The increase in factor Xa protein during prothrombin activation is due to incorporation of a non-active protein into the fraction. Prothrombin Activating Derivative B (PAD-B) is activated by concentrated salt solutions and not by stypven.

* This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas.


 

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